A systematic review of clear aligners in growing patients explores their efficacy, safety, and acceptability in managing mixed dentition. The review includes randomized controlled trials, cohorts, and observational studies, assessing clinical, radiographic, and psychosocial outcomes. Clear aligners offer an aesthetically pleasing and comfortable alternative to traditional orthodontic appliances, particularly for young patients. The study highlights the potential of aligners in addressing malocclusions, improving dental and skeletal development, and enhancing periodontal health. However, the application of aligners in growing patients remains underexplored, with limited evidence on long-term stability and effectiveness. The review identifies gaps in current research and suggests future studies to refine treatment guidelines and improve patient outcomes. Key findings include the effectiveness of aligners in correcting Class II malocclusions, achieving palatal expansion, and improving gingival health. Despite these benefits, challenges such as treatment complexity, patient compliance, and the need for individualized treatment plans remain. The review emphasizes the importance of evidence-based orthodontic practices and the role of clear aligners in modern pediatric orthodontics.A systematic review of clear aligners in growing patients explores their efficacy, safety, and acceptability in managing mixed dentition. The review includes randomized controlled trials, cohorts, and observational studies, assessing clinical, radiographic, and psychosocial outcomes. Clear aligners offer an aesthetically pleasing and comfortable alternative to traditional orthodontic appliances, particularly for young patients. The study highlights the potential of aligners in addressing malocclusions, improving dental and skeletal development, and enhancing periodontal health. However, the application of aligners in growing patients remains underexplored, with limited evidence on long-term stability and effectiveness. The review identifies gaps in current research and suggests future studies to refine treatment guidelines and improve patient outcomes. Key findings include the effectiveness of aligners in correcting Class II malocclusions, achieving palatal expansion, and improving gingival health. Despite these benefits, challenges such as treatment complexity, patient compliance, and the need for individualized treatment plans remain. The review emphasizes the importance of evidence-based orthodontic practices and the role of clear aligners in modern pediatric orthodontics.