A study published in *Nature* (2018) investigates the role of senescent glial cells in tau-dependent neurodegenerative diseases. The research shows that clearing senescent cells in a mouse model of tauopathy significantly reduces neurodegeneration, tau pathology, and cognitive decline. Senescent cells, characterized by cell cycle arrest and secretory phenotypes, accumulate with age and contribute to tissue dysfunction. In the PS19 mouse model, which expresses a mutant human tau protein, senescent astrocytes and microglia accumulate, leading to neurofibrillary tangle formation and neuronal loss. Using the INK-ATTAC transgene, researchers cleared these senescent cells, which reduced gliosis, tau hyperphosphorylation, and neuronal degeneration, preserving cognitive function. Pharmacological senolytic agents like ABT263 also reduced tau pathology and improved cognitive outcomes. The study suggests that targeting senescent cells could be a therapeutic strategy for tauopathies and other age-related diseases. The findings highlight the importance of early intervention in neurodegenerative diseases and provide a potential avenue for developing treatments targeting senescent cells.A study published in *Nature* (2018) investigates the role of senescent glial cells in tau-dependent neurodegenerative diseases. The research shows that clearing senescent cells in a mouse model of tauopathy significantly reduces neurodegeneration, tau pathology, and cognitive decline. Senescent cells, characterized by cell cycle arrest and secretory phenotypes, accumulate with age and contribute to tissue dysfunction. In the PS19 mouse model, which expresses a mutant human tau protein, senescent astrocytes and microglia accumulate, leading to neurofibrillary tangle formation and neuronal loss. Using the INK-ATTAC transgene, researchers cleared these senescent cells, which reduced gliosis, tau hyperphosphorylation, and neuronal degeneration, preserving cognitive function. Pharmacological senolytic agents like ABT263 also reduced tau pathology and improved cognitive outcomes. The study suggests that targeting senescent cells could be a therapeutic strategy for tauopathies and other age-related diseases. The findings highlight the importance of early intervention in neurodegenerative diseases and provide a potential avenue for developing treatments targeting senescent cells.