This study investigates the recent expansion and exacerbation of dengue transmission in Brazil from 2014 to 2020, using data-mining techniques to identify climatic and demographic factors. The central region of Brazil, previously a barrier to dengue transmission, has seen increased incidence rates due to previous virus circulation, urbanization, and prolonged temperature anomalies. High-altitude regions, which were once barriers, now experience high dengue incidence. The study developed an algorithm to assess future climate scenarios and plan preventive actions. The distribution of dengue and other arboviruses has shifted towards higher latitudes and altitudes, influenced by vector adaptability and incomplete urbanization. Temperature is a key factor in mosquito reproduction and dengue transmission, with optimal ranges between 21-30°C. The study found that temperature anomalies, urbanization, and previous dengue incidence rates are significant predictors of dengue incidence. The results highlight the irreversible expansion of dengue transmission areas and the need for early warning systems to address the medium and long-term effects of global warming.This study investigates the recent expansion and exacerbation of dengue transmission in Brazil from 2014 to 2020, using data-mining techniques to identify climatic and demographic factors. The central region of Brazil, previously a barrier to dengue transmission, has seen increased incidence rates due to previous virus circulation, urbanization, and prolonged temperature anomalies. High-altitude regions, which were once barriers, now experience high dengue incidence. The study developed an algorithm to assess future climate scenarios and plan preventive actions. The distribution of dengue and other arboviruses has shifted towards higher latitudes and altitudes, influenced by vector adaptability and incomplete urbanization. Temperature is a key factor in mosquito reproduction and dengue transmission, with optimal ranges between 21-30°C. The study found that temperature anomalies, urbanization, and previous dengue incidence rates are significant predictors of dengue incidence. The results highlight the irreversible expansion of dengue transmission areas and the need for early warning systems to address the medium and long-term effects of global warming.