A randomized clinical trial evaluated the effectiveness of paraprobiotics in improving periodontal health in pregnant women with periodontitis. Thirty pregnant women were divided into two groups: one using a paraprobiotic-based toothpaste and mousse twice daily, and the other using only the toothpaste. Assessments were conducted at 1, 3, and 6 months, as well as during pregnancy and postpartum. Key indices such as clinical attachment loss (CAL), probing pocket depth (PPD), bleeding on probing (BOP), plaque control record (PCR), and gingival indices were measured. The results showed that the combination of the toothpaste and mousse significantly reduced BOP and plaque control over time, although no significant differences were found between the two treatments. Both groups experienced gradual improvements in most indices, with no significant differences between or within groups. The test group showed a trend toward better stabilization of recessions. No adverse effects were reported during the study. The study suggests that paraprobiotic-based products may be effective in managing periodontal health in pregnant women, though further research is needed to confirm these findings and explore the long-term effects. The use of paraprobiotics appears to be safe and may offer benefits in reducing periodontal inflammation and plaque accumulation. The study highlights the importance of oral health education and the potential role of paraprobiotics in improving periodontal health during pregnancy.A randomized clinical trial evaluated the effectiveness of paraprobiotics in improving periodontal health in pregnant women with periodontitis. Thirty pregnant women were divided into two groups: one using a paraprobiotic-based toothpaste and mousse twice daily, and the other using only the toothpaste. Assessments were conducted at 1, 3, and 6 months, as well as during pregnancy and postpartum. Key indices such as clinical attachment loss (CAL), probing pocket depth (PPD), bleeding on probing (BOP), plaque control record (PCR), and gingival indices were measured. The results showed that the combination of the toothpaste and mousse significantly reduced BOP and plaque control over time, although no significant differences were found between the two treatments. Both groups experienced gradual improvements in most indices, with no significant differences between or within groups. The test group showed a trend toward better stabilization of recessions. No adverse effects were reported during the study. The study suggests that paraprobiotic-based products may be effective in managing periodontal health in pregnant women, though further research is needed to confirm these findings and explore the long-term effects. The use of paraprobiotics appears to be safe and may offer benefits in reducing periodontal inflammation and plaque accumulation. The study highlights the importance of oral health education and the potential role of paraprobiotics in improving periodontal health during pregnancy.