This study investigates the clinical and immunological characteristics of asymptomatic individuals infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The researchers studied 37 asymptomatic individuals in Wanzhou District, China, who were diagnosed with RT-PCR-confirmed SARS-CoV-2 infections but showed no relevant clinical symptoms over the preceding 14 days and during hospitalization. The median duration of viral shedding in the asymptomatic group was 19 days, significantly longer than in the symptomatic group (log-rank P = 0.028). Virus-specific IgG levels in the asymptomatic group were significantly lower than in the symptomatic group in the acute phase (P = 0.005). In the early convalescent phase, 93.3% of asymptomatic individuals and 96.8% of symptomatic individuals experienced a reduction in IgG levels, with a median percentage decrease of 71.1% and 76.2%, respectively. Additionally, 40% of asymptomatic individuals became seronegative, compared to 12.9% of symptomatic individuals. The asymptomatic group also exhibited lower levels of 18 pro- and anti-inflammatory cytokines, suggesting a weaker immune response to SARS-CoV-2 infection. These findings highlight the importance of understanding the immune responses and viral shedding duration in asymptomatic individuals to inform public health strategies and serological surveys.This study investigates the clinical and immunological characteristics of asymptomatic individuals infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The researchers studied 37 asymptomatic individuals in Wanzhou District, China, who were diagnosed with RT-PCR-confirmed SARS-CoV-2 infections but showed no relevant clinical symptoms over the preceding 14 days and during hospitalization. The median duration of viral shedding in the asymptomatic group was 19 days, significantly longer than in the symptomatic group (log-rank P = 0.028). Virus-specific IgG levels in the asymptomatic group were significantly lower than in the symptomatic group in the acute phase (P = 0.005). In the early convalescent phase, 93.3% of asymptomatic individuals and 96.8% of symptomatic individuals experienced a reduction in IgG levels, with a median percentage decrease of 71.1% and 76.2%, respectively. Additionally, 40% of asymptomatic individuals became seronegative, compared to 12.9% of symptomatic individuals. The asymptomatic group also exhibited lower levels of 18 pro- and anti-inflammatory cytokines, suggesting a weaker immune response to SARS-CoV-2 infection. These findings highlight the importance of understanding the immune responses and viral shedding duration in asymptomatic individuals to inform public health strategies and serological surveys.