A study of 1713 adult survivors of childhood cancer, followed for up to 5 years, found high prevalence of adverse health outcomes, with pulmonary, auditory, endocrine-reproductive, cardiac, and neurocognitive functions being most affected. These outcomes were often linked to cancer treatments. The study used systematic clinical assessments to evaluate health conditions, revealing that 95.2% of survivors had at least one chronic health condition by age 45, with 80% having a serious or disabling condition. Endocrine-reproductive disorders had the highest attributable fraction (88.4%), while conditions like hypertension and obesity had lower fractions. The study also identified a high prevalence of subsequent neoplasms, with 272 survivors developing one or more. The findings highlight the need for ongoing health monitoring and intervention for this population, as many conditions are previously undiagnosed. The study underscores the importance of risk-based screening and long-term follow-up to address the significant health burden in childhood cancer survivors. The results provide critical data for health screening recommendations and interventions. The study was conducted as part of the St. Jude Lifetime Cohort Study, which aims to evaluate long-term health outcomes in survivors of childhood cancer. The study found that many health issues are common in older populations, suggesting accelerated aging in survivors. The results emphasize the need for continued clinical evaluation and monitoring of this vulnerable group. The study also highlights the importance of considering treatment-related factors in health outcomes and the need for further research into the long-term effects of cancer treatments. The findings have implications for improving health care for childhood cancer survivors and guiding future research and interventions.A study of 1713 adult survivors of childhood cancer, followed for up to 5 years, found high prevalence of adverse health outcomes, with pulmonary, auditory, endocrine-reproductive, cardiac, and neurocognitive functions being most affected. These outcomes were often linked to cancer treatments. The study used systematic clinical assessments to evaluate health conditions, revealing that 95.2% of survivors had at least one chronic health condition by age 45, with 80% having a serious or disabling condition. Endocrine-reproductive disorders had the highest attributable fraction (88.4%), while conditions like hypertension and obesity had lower fractions. The study also identified a high prevalence of subsequent neoplasms, with 272 survivors developing one or more. The findings highlight the need for ongoing health monitoring and intervention for this population, as many conditions are previously undiagnosed. The study underscores the importance of risk-based screening and long-term follow-up to address the significant health burden in childhood cancer survivors. The results provide critical data for health screening recommendations and interventions. The study was conducted as part of the St. Jude Lifetime Cohort Study, which aims to evaluate long-term health outcomes in survivors of childhood cancer. The study found that many health issues are common in older populations, suggesting accelerated aging in survivors. The results emphasize the need for continued clinical evaluation and monitoring of this vulnerable group. The study also highlights the importance of considering treatment-related factors in health outcomes and the need for further research into the long-term effects of cancer treatments. The findings have implications for improving health care for childhood cancer survivors and guiding future research and interventions.