The article discusses the clinical consequences of polypharmacy, defined as the use of multiple drugs or more than are medically necessary, in elderly patients. It highlights the prevalence of polypharmacy and unnecessary medication use, which is particularly high in nursing home residents. The negative consequences of polypharmacy include increased healthcare costs, adverse drug events (ADEs), drug interactions, medication non-adherence, reduced functional capacity, and various geriatric syndromes such as cognitive impairment, falls, urinary incontinence, and nutritional issues. The article also reviews evidence from randomized controlled trials showing that inter-professional interventions, often involving clinical pharmacists, can effectively reduce unnecessary drug use and improve prescribing quality, although the impact on long-term health outcomes is mixed. The authors emphasize the need for further research to develop and implement innovative interventions to reduce polypharmacy and its associated risks.The article discusses the clinical consequences of polypharmacy, defined as the use of multiple drugs or more than are medically necessary, in elderly patients. It highlights the prevalence of polypharmacy and unnecessary medication use, which is particularly high in nursing home residents. The negative consequences of polypharmacy include increased healthcare costs, adverse drug events (ADEs), drug interactions, medication non-adherence, reduced functional capacity, and various geriatric syndromes such as cognitive impairment, falls, urinary incontinence, and nutritional issues. The article also reviews evidence from randomized controlled trials showing that inter-professional interventions, often involving clinical pharmacists, can effectively reduce unnecessary drug use and improve prescribing quality, although the impact on long-term health outcomes is mixed. The authors emphasize the need for further research to develop and implement innovative interventions to reduce polypharmacy and its associated risks.