This study provides a comprehensive analysis of 135 hospitalized patients with COVID-19 in northeast Chongqing, China. The median age of the patients was 47 years, with no significant gender difference. Most patients had contact with individuals from Wuhan, and 31.9% had underlying diseases such as hypertension, diabetes, cardiovascular disease, and malignancy. Common symptoms included fever (88.9%), cough (76.5%), and fatigue (32.5%). Chest CT scans revealed bilateral patchy shadows or ground glass opacity in all patients. Treatment included antiviral therapy (100%), antibacterial therapy (43.7%), and corticosteroids (26.7%). Traditional Chinese medicine (TCM) was used by 91.8% of patients. Severe cases were older and had more comorbidities. The 28-day mortality rate was 2.5%, and the study suggests early use of Kaletra and a combination of Western and TCM treatments. The findings contribute to a better understanding of the clinical features and treatment of COVID-19 in this region.This study provides a comprehensive analysis of 135 hospitalized patients with COVID-19 in northeast Chongqing, China. The median age of the patients was 47 years, with no significant gender difference. Most patients had contact with individuals from Wuhan, and 31.9% had underlying diseases such as hypertension, diabetes, cardiovascular disease, and malignancy. Common symptoms included fever (88.9%), cough (76.5%), and fatigue (32.5%). Chest CT scans revealed bilateral patchy shadows or ground glass opacity in all patients. Treatment included antiviral therapy (100%), antibacterial therapy (43.7%), and corticosteroids (26.7%). Traditional Chinese medicine (TCM) was used by 91.8% of patients. Severe cases were older and had more comorbidities. The 28-day mortality rate was 2.5%, and the study suggests early use of Kaletra and a combination of Western and TCM treatments. The findings contribute to a better understanding of the clinical features and treatment of COVID-19 in this region.