Chikungunya is a mosquito-borne viral disease characterized by acute symptoms such as fever and arthralgia, which can last 7-10 days. However, debilitating symptoms can persist for months or years. This systematic literature review and meta-analysis aimed to assess the clinical burden of chikungunya, focusing on its clinical manifestations, prevalence, duration, and hospitalization rates. The review identified 316 articles, and 11 meta-analyses were conducted to quantify pooled estimates on clinical outcomes, symptomatic rate, mortality rate, and hospitalization rate. The results showed that arthralgia was the most prevalent symptom in 90% of cases, followed by fever in 88%. The overall symptomatic rate was 75%, the chronicity rate was 44%, and the mortality rate was 0.3%. The study highlighted the substantial clinical burden of chikungunya, emphasizing the need for better understanding and management of the disease to improve public health intervention strategies and global surveillance.Chikungunya is a mosquito-borne viral disease characterized by acute symptoms such as fever and arthralgia, which can last 7-10 days. However, debilitating symptoms can persist for months or years. This systematic literature review and meta-analysis aimed to assess the clinical burden of chikungunya, focusing on its clinical manifestations, prevalence, duration, and hospitalization rates. The review identified 316 articles, and 11 meta-analyses were conducted to quantify pooled estimates on clinical outcomes, symptomatic rate, mortality rate, and hospitalization rate. The results showed that arthralgia was the most prevalent symptom in 90% of cases, followed by fever in 88%. The overall symptomatic rate was 75%, the chronicity rate was 44%, and the mortality rate was 0.3%. The study highlighted the substantial clinical burden of chikungunya, emphasizing the need for better understanding and management of the disease to improve public health intervention strategies and global surveillance.