The article discusses primary ovarian insufficiency (POI), a condition characterized by amenorrhea and elevated follicle-stimulating hormone (FSH) levels in women under 40 years old. The condition is often idiopathic, but can be associated with genetic mutations, autoimmune disorders, or structural abnormalities. Evaluation involves ruling out pregnancy, assessing stress, and performing hormonal and imaging tests. Management includes hormone replacement therapy to address estrogen deficiency, maintaining bone health, and addressing associated disorders. Emotional support is crucial, as POI can lead to significant psychological distress. The article emphasizes the importance of early diagnosis and management to improve quality of life and fertility outcomes.The article discusses primary ovarian insufficiency (POI), a condition characterized by amenorrhea and elevated follicle-stimulating hormone (FSH) levels in women under 40 years old. The condition is often idiopathic, but can be associated with genetic mutations, autoimmune disorders, or structural abnormalities. Evaluation involves ruling out pregnancy, assessing stress, and performing hormonal and imaging tests. Management includes hormone replacement therapy to address estrogen deficiency, maintaining bone health, and addressing associated disorders. Emotional support is crucial, as POI can lead to significant psychological distress. The article emphasizes the importance of early diagnosis and management to improve quality of life and fertility outcomes.