The Clinician’s Guide to Prevention and Treatment of Osteoporosis, developed by the National Osteoporosis Foundation (NOF) in collaboration with a multispecialty council of medical experts, provides comprehensive recommendations for the prevention, diagnosis, and treatment of osteoporosis in postmenopausal women and men aged 50 and older. The guide emphasizes the importance of early diagnosis and intervention to reduce the risk of fractures, which are common and have significant medical, personal, and economic impacts. Key recommendations include annual height measurement, regular bone mineral density (BMD) testing, and vertebral imaging for diagnosis. Pharmacologic treatments such as bisphosphonates, calcitonin, and others are recommended based on fracture risk and BMD status. The guide also highlights the importance of lifestyle interventions, including adequate calcium and vitamin D intake, regular weight-bearing exercise, and fall prevention strategies. The use of FRAX® for risk assessment and the FDA-approved drugs for osteoporosis treatment are discussed, along with safety considerations and side effects.The Clinician’s Guide to Prevention and Treatment of Osteoporosis, developed by the National Osteoporosis Foundation (NOF) in collaboration with a multispecialty council of medical experts, provides comprehensive recommendations for the prevention, diagnosis, and treatment of osteoporosis in postmenopausal women and men aged 50 and older. The guide emphasizes the importance of early diagnosis and intervention to reduce the risk of fractures, which are common and have significant medical, personal, and economic impacts. Key recommendations include annual height measurement, regular bone mineral density (BMD) testing, and vertebral imaging for diagnosis. Pharmacologic treatments such as bisphosphonates, calcitonin, and others are recommended based on fracture risk and BMD status. The guide also highlights the importance of lifestyle interventions, including adequate calcium and vitamin D intake, regular weight-bearing exercise, and fall prevention strategies. The use of FRAX® for risk assessment and the FDA-approved drugs for osteoporosis treatment are discussed, along with safety considerations and side effects.