2020 | Louise Lansbury, Benjamin Lim, Vadsala Baskaran, Wei Shen Lim
Since January 2020, Elsevier has created a free COVID-19 resource centre with information in English and Mandarin. The centre is hosted on Elsevier Connect, and Elsevier grants permission for free access to its research in PubMed Central and other repositories. A systematic review and meta-analysis on co-infections in patients with COVID-19 found that 7% of hospitalised patients had bacterial co-infections, with higher rates in ICU patients. Common bacteria included Mycoplasma pneumoniae, Pseudomonas aeruginosa, and Haemophilus influenzae. Viral co-infections were found in 3% of patients, with Respiratory Syncytial Virus and influenza A being the most common. Fungal co-infections were rare. The study concluded that bacterial co-infections are less common in COVID-19 than in previous influenza pandemics, suggesting that routine antibiotic use is not necessary. The review also highlighted the need for further research on fungal infections and the importance of judicious antibiotic use due to rising antimicrobial resistance. The study included 3834 patients from 29 observational studies and one RCT, with most data from China. The findings suggest that the proportion of co-infections is lower than in influenza, and that the majority of patients do not require hospitalisation. The study also noted significant heterogeneity in the data, and the need for further research as the pandemic evolves. The results support stopping empirical antibiotics in most cases of confirmed COVID-19.Since January 2020, Elsevier has created a free COVID-19 resource centre with information in English and Mandarin. The centre is hosted on Elsevier Connect, and Elsevier grants permission for free access to its research in PubMed Central and other repositories. A systematic review and meta-analysis on co-infections in patients with COVID-19 found that 7% of hospitalised patients had bacterial co-infections, with higher rates in ICU patients. Common bacteria included Mycoplasma pneumoniae, Pseudomonas aeruginosa, and Haemophilus influenzae. Viral co-infections were found in 3% of patients, with Respiratory Syncytial Virus and influenza A being the most common. Fungal co-infections were rare. The study concluded that bacterial co-infections are less common in COVID-19 than in previous influenza pandemics, suggesting that routine antibiotic use is not necessary. The review also highlighted the need for further research on fungal infections and the importance of judicious antibiotic use due to rising antimicrobial resistance. The study included 3834 patients from 29 observational studies and one RCT, with most data from China. The findings suggest that the proportion of co-infections is lower than in influenza, and that the majority of patients do not require hospitalisation. The study also noted significant heterogeneity in the data, and the need for further research as the pandemic evolves. The results support stopping empirical antibiotics in most cases of confirmed COVID-19.