This review discusses the latest advancements in coatings for cardiovascular stents, focusing on both organic and inorganic materials. Cardiovascular diseases (CVDs) are a major global health issue, and stents are essential for treating arterial blockages. While bare-metal stents (BMSs) were initially used, they often led to in-stent restenosis. Drug-eluting stents (DESs) were developed to address this, using polymers to deliver medication and reduce restenosis. However, DESs still face challenges such as in-stent thrombosis and inflammation. The review highlights the importance of biocompatible coatings that promote endothelialization and reduce adverse reactions. Organic coatings, including synthetic and natural polymers, as well as materials like heparin, hyaluronic acid, and fibrin, are discussed for their potential in improving stent performance. Inorganic coatings, such as titanium and magnesium-based materials, are also explored for their biocompatibility and degradation properties. The review emphasizes the need for further research to optimize stent coatings and improve clinical outcomes. It also addresses the challenges of polymer-based coatings, including inflammation and thrombosis, and highlights the potential of biodegradable polymers and polymer-free stents. The study concludes that while DESs have significantly improved treatment outcomes, ongoing research is necessary to enhance their safety and effectiveness.This review discusses the latest advancements in coatings for cardiovascular stents, focusing on both organic and inorganic materials. Cardiovascular diseases (CVDs) are a major global health issue, and stents are essential for treating arterial blockages. While bare-metal stents (BMSs) were initially used, they often led to in-stent restenosis. Drug-eluting stents (DESs) were developed to address this, using polymers to deliver medication and reduce restenosis. However, DESs still face challenges such as in-stent thrombosis and inflammation. The review highlights the importance of biocompatible coatings that promote endothelialization and reduce adverse reactions. Organic coatings, including synthetic and natural polymers, as well as materials like heparin, hyaluronic acid, and fibrin, are discussed for their potential in improving stent performance. Inorganic coatings, such as titanium and magnesium-based materials, are also explored for their biocompatibility and degradation properties. The review emphasizes the need for further research to optimize stent coatings and improve clinical outcomes. It also addresses the challenges of polymer-based coatings, including inflammation and thrombosis, and highlights the potential of biodegradable polymers and polymer-free stents. The study concludes that while DESs have significantly improved treatment outcomes, ongoing research is necessary to enhance their safety and effectiveness.