Collagen-based scaffolds are promising materials for treating chronic skin wounds, particularly in cases of infection and diabetes. Chronic wounds, such as ulcers, are challenging to treat due to slow or absent healing, often caused by internal and external factors. Traditional treatments are insufficient, prompting the exploration of regenerative medicine and tissue engineering. Collagen, a key component of the extracellular matrix, is biocompatible and biodegradable, making it suitable for scaffolds that promote tissue regeneration. These scaffolds can be functionalized with other biopolymers to enhance their properties, such as angiogenesis, anti-inflammatory effects, and antibacterial activity. Chronic wounds, including diabetic foot ulcers and pressure ulcers, are associated with persistent inflammation, oxidative stress, and microbial infections. Scaffolds can address these issues by promoting angiogenesis, reducing inflammation, and combating bacterial infections. For example, collagen scaffolds combined with growth factors like VEGF and Bcl-2 have shown promise in accelerating wound healing. Additionally, scaffolds functionalized with anti-inflammatory agents like thymosin beta 4 and MMP-9 inhibitors can modulate the inflammatory response and improve tissue regeneration. Antioxidant properties are also crucial in wound healing, as oxidative stress can impair the healing process. N-acetylcysteine (NAC) and polydatin, both antioxidants, have been incorporated into scaffolds to reduce ROS levels and enhance healing. Furthermore, scaffolds with antibacterial properties, such as those containing silver nanoparticles or mupirocin, can prevent infections and improve wound closure. The design of scaffolds involves considerations of material, functionalization, and additives to optimize their performance. For instance, scaffolds with collagen and chitosan have shown enhanced mechanical properties and biocompatibility. Additionally, scaffolds incorporating natural extracts like Pistacia lentiscus and Calendula officinalis have demonstrated improved wound healing outcomes. In summary, collagen-based scaffolds, when appropriately designed and functionalized, offer a promising approach for treating chronic skin wounds by promoting tissue regeneration, reducing inflammation, and combating infections. These scaffolds represent a significant advancement in regenerative medicine and tissue engineering, offering potential solutions for improving wound healing and patient outcomes.Collagen-based scaffolds are promising materials for treating chronic skin wounds, particularly in cases of infection and diabetes. Chronic wounds, such as ulcers, are challenging to treat due to slow or absent healing, often caused by internal and external factors. Traditional treatments are insufficient, prompting the exploration of regenerative medicine and tissue engineering. Collagen, a key component of the extracellular matrix, is biocompatible and biodegradable, making it suitable for scaffolds that promote tissue regeneration. These scaffolds can be functionalized with other biopolymers to enhance their properties, such as angiogenesis, anti-inflammatory effects, and antibacterial activity. Chronic wounds, including diabetic foot ulcers and pressure ulcers, are associated with persistent inflammation, oxidative stress, and microbial infections. Scaffolds can address these issues by promoting angiogenesis, reducing inflammation, and combating bacterial infections. For example, collagen scaffolds combined with growth factors like VEGF and Bcl-2 have shown promise in accelerating wound healing. Additionally, scaffolds functionalized with anti-inflammatory agents like thymosin beta 4 and MMP-9 inhibitors can modulate the inflammatory response and improve tissue regeneration. Antioxidant properties are also crucial in wound healing, as oxidative stress can impair the healing process. N-acetylcysteine (NAC) and polydatin, both antioxidants, have been incorporated into scaffolds to reduce ROS levels and enhance healing. Furthermore, scaffolds with antibacterial properties, such as those containing silver nanoparticles or mupirocin, can prevent infections and improve wound closure. The design of scaffolds involves considerations of material, functionalization, and additives to optimize their performance. For instance, scaffolds with collagen and chitosan have shown enhanced mechanical properties and biocompatibility. Additionally, scaffolds incorporating natural extracts like Pistacia lentiscus and Calendula officinalis have demonstrated improved wound healing outcomes. In summary, collagen-based scaffolds, when appropriately designed and functionalized, offer a promising approach for treating chronic skin wounds by promoting tissue regeneration, reducing inflammation, and combating infections. These scaffolds represent a significant advancement in regenerative medicine and tissue engineering, offering potential solutions for improving wound healing and patient outcomes.