The article "Colloids with Valence and Specific Directional Bonding" by Wang et al. (2012) presents a method for creating colloidal particles with chemically functionalized patches that can form highly directional bonds, mimicking the valence and directional bonding properties of atoms. These "colloidal atoms" possess various symmetries, including $sp$, $sp^2$, $sp^3$, $sp^3d$, $sp^3d^2$, and $sp^3d^3$. The patches are functionalized with DNA, enabling programmable, specific, and reversible interactions between particles, which facilitates the self-assembly of "colloidal molecules" with complex structures. The authors demonstrate the synthesis and assembly of colloidal particles with directional interactions, allowing for the creation of a wide range of colloidal molecules and macromolecules. The method involves a two-stage swelling process followed by polymerization, resulting in particles with various numbers of patches and symmetries. The self-assembly of these particles is observed under optical microscopy, providing insights into the kinetics and mechanisms of colloidal assembly. The ability to design colloidal particles with controlled bonding symmetries opens new possibilities for creating complex micro-structured materials.The article "Colloids with Valence and Specific Directional Bonding" by Wang et al. (2012) presents a method for creating colloidal particles with chemically functionalized patches that can form highly directional bonds, mimicking the valence and directional bonding properties of atoms. These "colloidal atoms" possess various symmetries, including $sp$, $sp^2$, $sp^3$, $sp^3d$, $sp^3d^2$, and $sp^3d^3$. The patches are functionalized with DNA, enabling programmable, specific, and reversible interactions between particles, which facilitates the self-assembly of "colloidal molecules" with complex structures. The authors demonstrate the synthesis and assembly of colloidal particles with directional interactions, allowing for the creation of a wide range of colloidal molecules and macromolecules. The method involves a two-stage swelling process followed by polymerization, resulting in particles with various numbers of patches and symmetries. The self-assembly of these particles is observed under optical microscopy, providing insights into the kinetics and mechanisms of colloidal assembly. The ability to design colloidal particles with controlled bonding symmetries opens new possibilities for creating complex micro-structured materials.