The article provides a comprehensive overview of colorectal cancer (CRC) statistics in the United States, including incidence, mortality, and survival rates. CRC is the third most common cancer among both men and women, with incidence and mortality rates declining over several decades due to changes in risk factors, screening tests, and treatment improvements. The incidence rates are highest in Alaska Natives and blacks, and lowest in Asian/Pacific Islanders, with a 30% to 40% higher rate in men than in women. Between 2000 and 2013, incidence rates in adults aged 50 years and older declined by 32%, with the largest drop in distal tumors in those aged 65 years and older. Overall CRC incidence in individuals aged 50 years and older declined from 2009 to 2013 in all states except Arkansas, with a 5% annual decrease in seven states. Among adults under 50 years, CRC incidence rates increased by 22% from 2000 to 2013, driven by tumors in the distal colon and rectum. CRC death rates decreased by 34% among individuals aged 50 years and older from 2000 to 2014, but increased by 13% in those under 50 years. The article highlights the importance of increasing screening rates, particularly in high-risk groups, and eliminating disparities in treatment to accelerate progress against CRC.The article provides a comprehensive overview of colorectal cancer (CRC) statistics in the United States, including incidence, mortality, and survival rates. CRC is the third most common cancer among both men and women, with incidence and mortality rates declining over several decades due to changes in risk factors, screening tests, and treatment improvements. The incidence rates are highest in Alaska Natives and blacks, and lowest in Asian/Pacific Islanders, with a 30% to 40% higher rate in men than in women. Between 2000 and 2013, incidence rates in adults aged 50 years and older declined by 32%, with the largest drop in distal tumors in those aged 65 years and older. Overall CRC incidence in individuals aged 50 years and older declined from 2009 to 2013 in all states except Arkansas, with a 5% annual decrease in seven states. Among adults under 50 years, CRC incidence rates increased by 22% from 2000 to 2013, driven by tumors in the distal colon and rectum. CRC death rates decreased by 34% among individuals aged 50 years and older from 2000 to 2014, but increased by 13% in those under 50 years. The article highlights the importance of increasing screening rates, particularly in high-risk groups, and eliminating disparities in treatment to accelerate progress against CRC.