The article discusses the communication mechanisms among oral bacteria, which are essential for the formation and maintenance of dental plaque. Oral bacteria have evolved sophisticated communication methods to coexist with their host, forming complex multispecies communities. These communities are dynamic and constantly changing, driven by physical interactions, metabolic exchanges, genetic exchanges, and signaling molecules produced by the host or other bacteria. The article highlights the importance of cell-to-cell recognition and autoinducer-2 signaling in these interactions. Early colonizers like Streptococcus gordonii and late colonizers like Fusobacterium nucleatum play crucial roles in establishing and maintaining these communities. The article also explores the architectural organization of dental plaque, both in vitro and in vivo, and the role of metabolic communication in these communities. Finally, it discusses the significance of these interactions in the development of dental diseases and the potential for therapeutic interventions.The article discusses the communication mechanisms among oral bacteria, which are essential for the formation and maintenance of dental plaque. Oral bacteria have evolved sophisticated communication methods to coexist with their host, forming complex multispecies communities. These communities are dynamic and constantly changing, driven by physical interactions, metabolic exchanges, genetic exchanges, and signaling molecules produced by the host or other bacteria. The article highlights the importance of cell-to-cell recognition and autoinducer-2 signaling in these interactions. Early colonizers like Streptococcus gordonii and late colonizers like Fusobacterium nucleatum play crucial roles in establishing and maintaining these communities. The article also explores the architectural organization of dental plaque, both in vitro and in vivo, and the role of metabolic communication in these communities. Finally, it discusses the significance of these interactions in the development of dental diseases and the potential for therapeutic interventions.