The article "Comparison of Multi-metallic Nanoparticles-Alternative Antibacterial Agent: Understanding the Role of Their Antibacterial Properties" by Parvathalu Kalakonda et al. addresses the growing concern of antibiotic-resistant infectious diseases caused by multidrug-resistant (MDR) bacteria. The authors highlight the potential of multi-metallic nanoparticles (MMNPs) as a promising alternative to combat these resistant pathogens. MMNPs, composed of multiple metals, exhibit unique physicochemical properties and excellent biocompatibility, which contribute to their strong antimicrobial activity. These properties, including size, shape, surface area to volume ratio, and surface charge potential, enable MMNPs to interact favorably with bacterial cell membranes, disrupting them, releasing metal ions, damaging biomolecules, generating reactive oxygen species (ROS), and causing DNA damage. The review provides a comprehensive summary of research progress on the antibacterial activities of MMNPs, their synergistic effects, and the mechanisms through which they exert their antibacterial effects. It also emphasizes recent advances in MMNPs that aid in overcoming antibacterial resistance, offering valuable insights into their potential applications in combating bacterial infections.The article "Comparison of Multi-metallic Nanoparticles-Alternative Antibacterial Agent: Understanding the Role of Their Antibacterial Properties" by Parvathalu Kalakonda et al. addresses the growing concern of antibiotic-resistant infectious diseases caused by multidrug-resistant (MDR) bacteria. The authors highlight the potential of multi-metallic nanoparticles (MMNPs) as a promising alternative to combat these resistant pathogens. MMNPs, composed of multiple metals, exhibit unique physicochemical properties and excellent biocompatibility, which contribute to their strong antimicrobial activity. These properties, including size, shape, surface area to volume ratio, and surface charge potential, enable MMNPs to interact favorably with bacterial cell membranes, disrupting them, releasing metal ions, damaging biomolecules, generating reactive oxygen species (ROS), and causing DNA damage. The review provides a comprehensive summary of research progress on the antibacterial activities of MMNPs, their synergistic effects, and the mechanisms through which they exert their antibacterial effects. It also emphasizes recent advances in MMNPs that aid in overcoming antibacterial resistance, offering valuable insights into their potential applications in combating bacterial infections.