This study compares the association of hypertension plus hyperuricemia (HTN-HUA) with seven anthropometric indexes: atherogenic index of plasma (AIP), lipid accumulation product (LAP), visceral adiposity index (VAI), triglyceride-glucose index (TyG), body roundness index (BRI), a body shape index (ABSI), and cardiometabolic index (CMI). Data from the National Health and Nutrition Examination Survey (NHANES) was analyzed, including 23,478 subjects. Multivariate logistic regression and ROC curve analyses were used to evaluate the predictive power of these indexes. The results showed that all seven indexes were significantly associated with HTN-HUA, with LAP and BRI demonstrating the highest discriminatory abilities. Specifically, the odds ratios for the highest quartile of the seven indexes for HTN-HUA were 4.45 for AIP, 9.52 for LAP, 4.53 for VAI, 4.91 for TyG, 9.08 for BRI, 1.71 for ABSI, and 6.57 for CMI. The study concludes that BRI is a superior choice for early detection and management of HTN-HUA due to its non-invasive nature and effective predictive capabilities.This study compares the association of hypertension plus hyperuricemia (HTN-HUA) with seven anthropometric indexes: atherogenic index of plasma (AIP), lipid accumulation product (LAP), visceral adiposity index (VAI), triglyceride-glucose index (TyG), body roundness index (BRI), a body shape index (ABSI), and cardiometabolic index (CMI). Data from the National Health and Nutrition Examination Survey (NHANES) was analyzed, including 23,478 subjects. Multivariate logistic regression and ROC curve analyses were used to evaluate the predictive power of these indexes. The results showed that all seven indexes were significantly associated with HTN-HUA, with LAP and BRI demonstrating the highest discriminatory abilities. Specifically, the odds ratios for the highest quartile of the seven indexes for HTN-HUA were 4.45 for AIP, 9.52 for LAP, 4.53 for VAI, 4.91 for TyG, 9.08 for BRI, 1.71 for ABSI, and 6.57 for CMI. The study concludes that BRI is a superior choice for early detection and management of HTN-HUA due to its non-invasive nature and effective predictive capabilities.