The article by Josias H. Hamman reviews the composition and applications of Aloe vera leaf gel, highlighting its biological activities and recent discoveries. Aloe vera, a perennial succulent, contains polysaccharides that are responsible for its therapeutic properties, including wound healing, antifungal activity, hypoglycemic effects, anti-inflammatory properties, anticancer effects, immunomodulation, and gastroprotective properties. The gel's polysaccharides, particularly acemannan, are key to these activities, though the synergistic effects of multiple compounds are also significant. The article discusses the potential of Aloe vera gel to enhance the intestinal absorption and bioavailability of co-administered compounds, as well as its ability to improve skin permeation. It also outlines pharmaceutical applications, such as using dried Aloe vera gel powder as an excipient in sustained-release dosage forms. The gel's ability to enhance drug absorption and its potential as a penetration enhancer are supported by in vitro and clinical studies. Additionally, the article reviews the biological activities of Aloe vera leaf gel, including its anti-diabetic, immunomodulatory, anti-inflammatory, antioxidant, wound healing, anti-cancer, and hepatoprotective effects. It highlights the importance of standardized production methods to preserve the gel's biological activity and the need for further research to fully understand its therapeutic potential.The article by Josias H. Hamman reviews the composition and applications of Aloe vera leaf gel, highlighting its biological activities and recent discoveries. Aloe vera, a perennial succulent, contains polysaccharides that are responsible for its therapeutic properties, including wound healing, antifungal activity, hypoglycemic effects, anti-inflammatory properties, anticancer effects, immunomodulation, and gastroprotective properties. The gel's polysaccharides, particularly acemannan, are key to these activities, though the synergistic effects of multiple compounds are also significant. The article discusses the potential of Aloe vera gel to enhance the intestinal absorption and bioavailability of co-administered compounds, as well as its ability to improve skin permeation. It also outlines pharmaceutical applications, such as using dried Aloe vera gel powder as an excipient in sustained-release dosage forms. The gel's ability to enhance drug absorption and its potential as a penetration enhancer are supported by in vitro and clinical studies. Additionally, the article reviews the biological activities of Aloe vera leaf gel, including its anti-diabetic, immunomodulatory, anti-inflammatory, antioxidant, wound healing, anti-cancer, and hepatoprotective effects. It highlights the importance of standardized production methods to preserve the gel's biological activity and the need for further research to fully understand its therapeutic potential.