Aloe vera leaf gel is a complex mixture of polysaccharides, proteins, lipids, vitamins, minerals, enzymes, and other compounds. It has been used for centuries for its therapeutic properties and is now widely applied in food, cosmetic, and pharmaceutical industries. The gel contains acetylated glucomannan (acemannan), a major polysaccharide responsible for its thick, mucilaginous properties. Recent studies have shown that Aloe vera gel can enhance the intestinal absorption and bioavailability of co-administered compounds, as well as improve skin permeation. It has also been used as an excipient in modified release dosage forms, such as direct compressible matrix tablets, which can slowly release drugs over an extended period. The gel has various biological activities, including immunomodulatory, anti-inflammatory, anti-oxidant, anti-diabetic, and anti-cancer effects. However, the exact mechanisms and the role of individual components in these activities are still under investigation. Some studies suggest that the gel may have antimicrobial properties against both Gram-positive and Gram-negative bacteria. Despite these benefits, there are conflicting results regarding its effectiveness, possibly due to variations in plant composition and extraction methods. Aloe vera gel has shown potential in enhancing the bioavailability of vitamins C and E, and in improving the absorption of macromolecular drugs like insulin. It also enhances skin penetration, which could be useful for transdermal drug delivery. However, its effectiveness may depend on the molecular weight of the compounds involved. Additionally, the gel has been shown to have hepatoprotective effects, reducing liver damage caused by carbon tetrachloride in mice. The gel's polysaccharide composition varies, and its stability is influenced by factors such as heat, acid, and enzymatic activity. Standardized production methods are necessary to maintain its biological activity. Overall, Aloe vera leaf gel has a wide range of applications and continues to be a subject of research for its potential therapeutic benefits.Aloe vera leaf gel is a complex mixture of polysaccharides, proteins, lipids, vitamins, minerals, enzymes, and other compounds. It has been used for centuries for its therapeutic properties and is now widely applied in food, cosmetic, and pharmaceutical industries. The gel contains acetylated glucomannan (acemannan), a major polysaccharide responsible for its thick, mucilaginous properties. Recent studies have shown that Aloe vera gel can enhance the intestinal absorption and bioavailability of co-administered compounds, as well as improve skin permeation. It has also been used as an excipient in modified release dosage forms, such as direct compressible matrix tablets, which can slowly release drugs over an extended period. The gel has various biological activities, including immunomodulatory, anti-inflammatory, anti-oxidant, anti-diabetic, and anti-cancer effects. However, the exact mechanisms and the role of individual components in these activities are still under investigation. Some studies suggest that the gel may have antimicrobial properties against both Gram-positive and Gram-negative bacteria. Despite these benefits, there are conflicting results regarding its effectiveness, possibly due to variations in plant composition and extraction methods. Aloe vera gel has shown potential in enhancing the bioavailability of vitamins C and E, and in improving the absorption of macromolecular drugs like insulin. It also enhances skin penetration, which could be useful for transdermal drug delivery. However, its effectiveness may depend on the molecular weight of the compounds involved. Additionally, the gel has been shown to have hepatoprotective effects, reducing liver damage caused by carbon tetrachloride in mice. The gel's polysaccharide composition varies, and its stability is influenced by factors such as heat, acid, and enzymatic activity. Standardized production methods are necessary to maintain its biological activity. Overall, Aloe vera leaf gel has a wide range of applications and continues to be a subject of research for its potential therapeutic benefits.