The CRISPR system is a revolutionary genome editing tool that has the potential to revolutionize cancer research and therapy. This review discusses various CRISPR-based strategies for cancer therapy, including inactivating oncogenes, enhancing the immune response, repairing genetic mutations, and delivering cancer-killing molecules. Preclinical studies and clinical trials have demonstrated promising results, but challenges such as off-target effects, safety, and delivery remain. The review highlights the most promising results and the need to address these challenges to realize the full potential of CRISPR-based cancer therapy. It also provides an overview of future research directions and the implications for the future of cancer treatment.The CRISPR system is a revolutionary genome editing tool that has the potential to revolutionize cancer research and therapy. This review discusses various CRISPR-based strategies for cancer therapy, including inactivating oncogenes, enhancing the immune response, repairing genetic mutations, and delivering cancer-killing molecules. Preclinical studies and clinical trials have demonstrated promising results, but challenges such as off-target effects, safety, and delivery remain. The review highlights the most promising results and the need to address these challenges to realize the full potential of CRISPR-based cancer therapy. It also provides an overview of future research directions and the implications for the future of cancer treatment.