The article "Compromised MAPK signaling in human diseases: an update" by Eun Kyung Kim and Eui-Ju Choi provides an overview of the roles of mitogen-activated protein kinases (MAPKs) in various cellular activities and their significance in human diseases, particularly cancer and neurodegenerative disorders. MAPKs, including c-Jun NH2-terminal kinase (JNK), p38 MAPK, and extracellular signal-regulated kinase (ERK), are serine-threonine protein kinases that regulate processes such as proliferation, differentiation, apoptosis, inflammation, and innate immunity. Compromised MAPK signaling pathways contribute to the pathology of diseases like cancer and neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis. The article highlights how JNK and p38 MAPK signaling pathways are activated by cellular stress and proinflammatory cytokines, while the Ras-Raf-MEK-ERK pathway plays a key role in cancer development through cell proliferation and metastasis. The p38 MAPK pathway is also associated with neuroinflammation and anticancer drug resistance in colon and liver cancer. The authors summarize recent research on the roles of MAPK signaling pathways in these diseases, emphasizing their importance in understanding and treating these conditions.The article "Compromised MAPK signaling in human diseases: an update" by Eun Kyung Kim and Eui-Ju Choi provides an overview of the roles of mitogen-activated protein kinases (MAPKs) in various cellular activities and their significance in human diseases, particularly cancer and neurodegenerative disorders. MAPKs, including c-Jun NH2-terminal kinase (JNK), p38 MAPK, and extracellular signal-regulated kinase (ERK), are serine-threonine protein kinases that regulate processes such as proliferation, differentiation, apoptosis, inflammation, and innate immunity. Compromised MAPK signaling pathways contribute to the pathology of diseases like cancer and neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis. The article highlights how JNK and p38 MAPK signaling pathways are activated by cellular stress and proinflammatory cytokines, while the Ras-Raf-MEK-ERK pathway plays a key role in cancer development through cell proliferation and metastasis. The p38 MAPK pathway is also associated with neuroinflammation and anticancer drug resistance in colon and liver cancer. The authors summarize recent research on the roles of MAPK signaling pathways in these diseases, emphasizing their importance in understanding and treating these conditions.