The paper provides an updated literature review on the influence of geographic factors on the spread of COVID-19. The review includes 112 scientific articles, categorized by subject area, aim, country/region of study, considered geographic and COVID-19 variables, spatial and temporal units of analysis, methodologies, and main findings. The study reveals that territorial features, climatic factors, and socio-demographic and socioeconomic conditions significantly influence the spread of COVID-19. Specifically, urbanization degree, temperature, population density, and human mobility are found to have a direct relationship with COVID-19 infections and deaths. The analysis also highlights that the significance and representativeness of the outputs are influenced by the scale of analysis, with studies conducted at subnational or local scales showing more robust associations between geographic factors and COVID-19 compared to country-scale studies. The review concludes by identifying research gaps and suggesting future directions for in-depth analyses.The paper provides an updated literature review on the influence of geographic factors on the spread of COVID-19. The review includes 112 scientific articles, categorized by subject area, aim, country/region of study, considered geographic and COVID-19 variables, spatial and temporal units of analysis, methodologies, and main findings. The study reveals that territorial features, climatic factors, and socio-demographic and socioeconomic conditions significantly influence the spread of COVID-19. Specifically, urbanization degree, temperature, population density, and human mobility are found to have a direct relationship with COVID-19 infections and deaths. The analysis also highlights that the significance and representativeness of the outputs are influenced by the scale of analysis, with studies conducted at subnational or local scales showing more robust associations between geographic factors and COVID-19 compared to country-scale studies. The review concludes by identifying research gaps and suggesting future directions for in-depth analyses.