The article reviews various experimental animal models of retinal degeneration, including induced and genetic models, highlighting their advantages and disadvantages. These models are essential for developing pathogenetic approaches to treat retinal diseases. The review covers models such as pigmentary retinopathy (PR), age-related macular degeneration (AMD), and Best disease, among others. Induced models, created through chemical, physical, and biological interventions, closely mimic morphological changes in human retinal degenerative diseases. Genetic models, on the other hand, are derived from spontaneous or transgenic mutations, offering insights into monogenic and multifactorial diseases. The choice of an appropriate experimental model can significantly impact the development of therapeutic strategies for retinal degenerative diseases. The article also discusses the limitations and challenges of using different animal models, emphasizing the need for a balanced approach to model selection based on the specific disease being studied.The article reviews various experimental animal models of retinal degeneration, including induced and genetic models, highlighting their advantages and disadvantages. These models are essential for developing pathogenetic approaches to treat retinal diseases. The review covers models such as pigmentary retinopathy (PR), age-related macular degeneration (AMD), and Best disease, among others. Induced models, created through chemical, physical, and biological interventions, closely mimic morphological changes in human retinal degenerative diseases. Genetic models, on the other hand, are derived from spontaneous or transgenic mutations, offering insights into monogenic and multifactorial diseases. The choice of an appropriate experimental model can significantly impact the development of therapeutic strategies for retinal degenerative diseases. The article also discusses the limitations and challenges of using different animal models, emphasizing the need for a balanced approach to model selection based on the specific disease being studied.