This review article explores the complex interplay between autophagy and epithelial mesenchymal transition (EMT) in cancer progression. Autophagy, a cellular degradation process, and EMT, a mechanism where epithelial cells acquire mesenchymal features, both play significant roles in cancer development. The study aims to understand how these processes interact, particularly how autophagy impacts cancer cell fate during EMT. The findings are expected to contribute to a better understanding of cancer biology and could potentially impact cancer treatment strategies, as both autophagy and EMT are considered targets for therapy. The article discusses the role of autophagy in cancer, highlighting its dual nature as both a tumor suppressor and a pro-survival mechanism. Autophagy can eliminate damaged organelles, promote cell survival under stress conditions, and influence DNA repair, cell adhesion, and differentiation. The review also examines the role of autophagy in cancer stem cell (CSC) maintenance, where it helps maintain stem cell-like properties and resistance to chemotherapy and radiation therapy. Additionally, the article explores the relationship between EMT and cancer progression, emphasizing its role in tumor invasion, metastasis, and drug resistance. EMT is associated with profound cellular changes, including cytoskeletal remodeling, loss of epithelial markers, and acquisition of mesenchymal markers. The review discusses the involvement of EMT transcription factors (EMT-TFs) and signaling pathways in promoting drug resistance and the potential of targeting these processes as therapeutic strategies. Finally, the article reviews the current state of clinical trials and experimental studies targeting autophagy and EMT in cancer treatment, highlighting the potential benefits and challenges of these approaches. The interplay between autophagy and EMT is a critical area of research that could lead to more effective cancer therapies.This review article explores the complex interplay between autophagy and epithelial mesenchymal transition (EMT) in cancer progression. Autophagy, a cellular degradation process, and EMT, a mechanism where epithelial cells acquire mesenchymal features, both play significant roles in cancer development. The study aims to understand how these processes interact, particularly how autophagy impacts cancer cell fate during EMT. The findings are expected to contribute to a better understanding of cancer biology and could potentially impact cancer treatment strategies, as both autophagy and EMT are considered targets for therapy. The article discusses the role of autophagy in cancer, highlighting its dual nature as both a tumor suppressor and a pro-survival mechanism. Autophagy can eliminate damaged organelles, promote cell survival under stress conditions, and influence DNA repair, cell adhesion, and differentiation. The review also examines the role of autophagy in cancer stem cell (CSC) maintenance, where it helps maintain stem cell-like properties and resistance to chemotherapy and radiation therapy. Additionally, the article explores the relationship between EMT and cancer progression, emphasizing its role in tumor invasion, metastasis, and drug resistance. EMT is associated with profound cellular changes, including cytoskeletal remodeling, loss of epithelial markers, and acquisition of mesenchymal markers. The review discusses the involvement of EMT transcription factors (EMT-TFs) and signaling pathways in promoting drug resistance and the potential of targeting these processes as therapeutic strategies. Finally, the article reviews the current state of clinical trials and experimental studies targeting autophagy and EMT in cancer treatment, highlighting the potential benefits and challenges of these approaches. The interplay between autophagy and EMT is a critical area of research that could lead to more effective cancer therapies.