The transcription factor NF-κB plays a crucial role in regulating genes involved in immune and inflammatory responses, as well as cell growth control. Its activation is linked to various aspects of oncogenesis, including apoptosis, cell cycle, differentiation, and migration. NF-κB is dysregulated in many forms of cancer, and its inhibition has been proposed as a therapeutic strategy for certain cancers. The regulation of NF-κB involves its interaction with IκB proteins, which control its nuclear localization and transcriptional activity. NF-κB is activated by viral oncoproteins and can promote oncogenesis by suppressing apoptosis, upregulating cell growth, and promoting metastasis. Inhibition of NF-κB can induce apoptosis and enhance the effectiveness of cancer therapies, such as chemotherapy and radiation. However, the complex regulatory mechanisms of NF-κB suggest that its inhibition may have both beneficial and adverse effects, depending on the context and type of cancer.The transcription factor NF-κB plays a crucial role in regulating genes involved in immune and inflammatory responses, as well as cell growth control. Its activation is linked to various aspects of oncogenesis, including apoptosis, cell cycle, differentiation, and migration. NF-κB is dysregulated in many forms of cancer, and its inhibition has been proposed as a therapeutic strategy for certain cancers. The regulation of NF-κB involves its interaction with IκB proteins, which control its nuclear localization and transcriptional activity. NF-κB is activated by viral oncoproteins and can promote oncogenesis by suppressing apoptosis, upregulating cell growth, and promoting metastasis. Inhibition of NF-κB can induce apoptosis and enhance the effectiveness of cancer therapies, such as chemotherapy and radiation. However, the complex regulatory mechanisms of NF-κB suggest that its inhibition may have both beneficial and adverse effects, depending on the context and type of cancer.