This systematic review and meta-analysis evaluates the effectiveness of interventions to reduce burnout in physicians. The study included 19 studies with 20 independent comparisons involving 1,550 physicians. The main outcome measure was burnout scores, specifically emotional exhaustion. The results showed that interventions were associated with small but significant reductions in burnout (Standardized Mean Difference [SMD]=-0.29, 95% CI=-0.42 to -0.16). Subgroup analyses indicated that organization-directed interventions were more effective than physician-directed interventions (SMD=-0.45, 95% CI=-0.62 to -0.28). Interventions for experienced physicians and those in primary care settings showed higher effects compared to less experienced physicians and secondary care settings, though these differences were not statistically significant. The findings suggest that current intervention programs for burnout in physicians are beneficial but modest, and that organization-directed approaches may be particularly effective. This supports the view that burnout is a problem of the entire healthcare organization rather than just individuals.This systematic review and meta-analysis evaluates the effectiveness of interventions to reduce burnout in physicians. The study included 19 studies with 20 independent comparisons involving 1,550 physicians. The main outcome measure was burnout scores, specifically emotional exhaustion. The results showed that interventions were associated with small but significant reductions in burnout (Standardized Mean Difference [SMD]=-0.29, 95% CI=-0.42 to -0.16). Subgroup analyses indicated that organization-directed interventions were more effective than physician-directed interventions (SMD=-0.45, 95% CI=-0.62 to -0.28). Interventions for experienced physicians and those in primary care settings showed higher effects compared to less experienced physicians and secondary care settings, though these differences were not statistically significant. The findings suggest that current intervention programs for burnout in physicians are beneficial but modest, and that organization-directed approaches may be particularly effective. This supports the view that burnout is a problem of the entire healthcare organization rather than just individuals.