A systematic review and meta-analysis of controlled interventions to reduce burnout in physicians found that interventions were associated with small but significant reductions in burnout, particularly in emotional exhaustion. Organization-directed interventions showed greater effectiveness compared to physician-directed ones. Interventions targeting experienced physicians and delivered in primary care were more effective than those targeting less experienced physicians in secondary care. However, these differences were not statistically significant. The study included 19 studies with 1,550 physicians, and the results were not influenced by the risk of bias. The findings suggest that current burnout intervention programs for physicians have small benefits, which may be enhanced by organization-directed approaches. This indicates that burnout is a systemic issue within healthcare organizations rather than an individual problem. The study highlights the importance of organizational changes and support for individual physicians in addressing burnout. The results emphasize the need for further research to understand the best contexts for delivering burnout interventions and to develop effective strategies for reducing burnout in physicians.A systematic review and meta-analysis of controlled interventions to reduce burnout in physicians found that interventions were associated with small but significant reductions in burnout, particularly in emotional exhaustion. Organization-directed interventions showed greater effectiveness compared to physician-directed ones. Interventions targeting experienced physicians and delivered in primary care were more effective than those targeting less experienced physicians in secondary care. However, these differences were not statistically significant. The study included 19 studies with 1,550 physicians, and the results were not influenced by the risk of bias. The findings suggest that current burnout intervention programs for physicians have small benefits, which may be enhanced by organization-directed approaches. This indicates that burnout is a systemic issue within healthcare organizations rather than an individual problem. The study highlights the importance of organizational changes and support for individual physicians in addressing burnout. The results emphasize the need for further research to understand the best contexts for delivering burnout interventions and to develop effective strategies for reducing burnout in physicians.