Alphaxalone-alphadolone (Althesin) was used as a controlled infusion for sedation in 30 patients in an intensive therapy unit. The technique allowed rapid and accurate control of sedation levels, providing "light sleep," rapid variation in sedation, and repeated assessment of the central nervous system. Sedation was satisfactory for 86% of the total time, with no serious complications. No evidence of tachyphylaxis or delayed recovery was observed despite prolonged use. The study highlights the advantages of alphaxalone-alphadolone in maintaining adequate sedation without prolonged unconsciousness, improving patient comfort and allowing for neurological assessments. However, it emphasizes the need for continuous supervision and monitoring to ensure safety.Alphaxalone-alphadolone (Althesin) was used as a controlled infusion for sedation in 30 patients in an intensive therapy unit. The technique allowed rapid and accurate control of sedation levels, providing "light sleep," rapid variation in sedation, and repeated assessment of the central nervous system. Sedation was satisfactory for 86% of the total time, with no serious complications. No evidence of tachyphylaxis or delayed recovery was observed despite prolonged use. The study highlights the advantages of alphaxalone-alphadolone in maintaining adequate sedation without prolonged unconsciousness, improving patient comfort and allowing for neurological assessments. However, it emphasizes the need for continuous supervision and monitoring to ensure safety.