The article "Convergence of Nanomedicine and Neutrophils for Drug Delivery" by Sichen Yuan and Quanyin Hu reviews the integration of neutrophils with nanotechnology to enhance drug delivery systems. Neutrophils, the most abundant leukocytes, are emerging as promising carriers due to their rapid response to inflammation, chemotaxis, and transmigration capabilities. When combined with nanotechnology, these properties can be leveraged to improve treatment efficacy and reduce side effects. The review covers the benefits, design principles, and applications of neutrophil-based nano-drug delivery systems. Key points include: - **Advantages of Neutrophils**: Neutrophils offer superior biocompatibility, targeting ability, and therapeutic robustness. - **Design Principles**: Strategies include coating nanoparticles with neutrophil membranes, loading nanoparticles inside living cells, and engineering chimeric antigen receptor (CAR)-neutrophils. - **Applications**: These systems have shown promise in treating various diseases, such as brain disorders (e.g., cerebral ischemia, glioma) and cancer (e.g., lung cancer, triple-negative breast cancer). - **Challenges**: Despite advancements, challenges remain, including achieving uniform coating integrity, optimizing loading efficiency, and ensuring controlled payload release. The article also discusses the unique tropisms and recruitment capabilities of neutrophils, which enable targeted drug delivery to specific sites within the body. Examples of successful applications include the use of neutrophil-based systems for treating ischemic brain damage and delivering chemotherapeutic drugs to glioma tumors. The review highlights the potential of neutrophil-based nano-drug delivery systems to address the limitations of traditional drug delivery methods and improve therapeutic outcomes.The article "Convergence of Nanomedicine and Neutrophils for Drug Delivery" by Sichen Yuan and Quanyin Hu reviews the integration of neutrophils with nanotechnology to enhance drug delivery systems. Neutrophils, the most abundant leukocytes, are emerging as promising carriers due to their rapid response to inflammation, chemotaxis, and transmigration capabilities. When combined with nanotechnology, these properties can be leveraged to improve treatment efficacy and reduce side effects. The review covers the benefits, design principles, and applications of neutrophil-based nano-drug delivery systems. Key points include: - **Advantages of Neutrophils**: Neutrophils offer superior biocompatibility, targeting ability, and therapeutic robustness. - **Design Principles**: Strategies include coating nanoparticles with neutrophil membranes, loading nanoparticles inside living cells, and engineering chimeric antigen receptor (CAR)-neutrophils. - **Applications**: These systems have shown promise in treating various diseases, such as brain disorders (e.g., cerebral ischemia, glioma) and cancer (e.g., lung cancer, triple-negative breast cancer). - **Challenges**: Despite advancements, challenges remain, including achieving uniform coating integrity, optimizing loading efficiency, and ensuring controlled payload release. The article also discusses the unique tropisms and recruitment capabilities of neutrophils, which enable targeted drug delivery to specific sites within the body. Examples of successful applications include the use of neutrophil-based systems for treating ischemic brain damage and delivering chemotherapeutic drugs to glioma tumors. The review highlights the potential of neutrophil-based nano-drug delivery systems to address the limitations of traditional drug delivery methods and improve therapeutic outcomes.