Covalent Organic Frameworks (COFs) are a class of crystalline porous materials with well-defined structures and high surface areas, offering unique properties for applications in separation, energy conversion, and electronics. This book explores the synthesis, properties, and applications of COFs, focusing on their interfacial synthesis and functionalization. The book is edited by Yanan Gao and Fei Lu, and includes contributions from various researchers in the field. The book discusses the synthesis of 2D COF thin films through different interfaces, such as gas/solid, liquid/liquid, liquid/solid, and gas/liquid interfaces. It also covers the use of COFs in photocatalysis, ion conduction, and cancer therapy. The book highlights the advantages and limitations of various synthesis methods, emphasizing the importance of controlling chemical bonding, morphology, and crystal structure. The authors emphasize the potential of COFs in various applications, including energy storage, environmental remediation, and biomedical applications. The book provides a comprehensive overview of the current state of COF research and development, and offers insights into future directions for this promising field.Covalent Organic Frameworks (COFs) are a class of crystalline porous materials with well-defined structures and high surface areas, offering unique properties for applications in separation, energy conversion, and electronics. This book explores the synthesis, properties, and applications of COFs, focusing on their interfacial synthesis and functionalization. The book is edited by Yanan Gao and Fei Lu, and includes contributions from various researchers in the field. The book discusses the synthesis of 2D COF thin films through different interfaces, such as gas/solid, liquid/liquid, liquid/solid, and gas/liquid interfaces. It also covers the use of COFs in photocatalysis, ion conduction, and cancer therapy. The book highlights the advantages and limitations of various synthesis methods, emphasizing the importance of controlling chemical bonding, morphology, and crystal structure. The authors emphasize the potential of COFs in various applications, including energy storage, environmental remediation, and biomedical applications. The book provides a comprehensive overview of the current state of COF research and development, and offers insights into future directions for this promising field.