The CIPRES Science Gateway is a web-based platform that provides researchers with access to powerful computational resources for inferring phylogenetic relationships. As DNA sequencing technologies have advanced, the volume of available genetic data has increased dramatically, making it essential to use scalable, high-performance computing resources for phylogenetic analysis. Traditional local computing resources are no longer sufficient, and the CIPRES Science Gateway was developed to address this need by offering access to the fastest available community codes for phylogenetic inference. The gateway was designed to meet the needs of the systematics community by providing a scalable, sustainable resource that allows users to run jobs requiring significant computational power. It includes features such as simple browser-based access to community tree inference codes, storage of uploaded files and job records, tailored interfaces for different user expertise levels, and easy access to the fastest available codes on scalable resources. The gateway also allows for the addition of new tools and updates to existing ones, and it minimizes job loss due to system errors or file format issues. The CIPRES Science Gateway was implemented using a new architecture called the Workbench Framework (WF), which allows for the deployment of analytical jobs and database searches on various computational resources. The gateway supports access to a wide range of computational resources, including TeraGrid resources, and provides a flexible and scalable solution for phylogenetic analysis. The gateway has been widely adopted, with over 1800 unique users running jobs that required 2.5 million Service Units since its release in December 2009. The gateway has proven to be a critical resource for the systematics community, enabling researchers to perform complex phylogenetic analyses that would be impractical with local computing resources. However, the increasing demand for computational resources has raised the need for effective management strategies to ensure fair access and sustainability. The gateway has implemented policies to manage resource usage, including limiting access for high-consumption users and requiring personal allocations for those who exceed certain thresholds. These measures ensure that the gateway remains a sustainable and accessible resource for the systematics community.The CIPRES Science Gateway is a web-based platform that provides researchers with access to powerful computational resources for inferring phylogenetic relationships. As DNA sequencing technologies have advanced, the volume of available genetic data has increased dramatically, making it essential to use scalable, high-performance computing resources for phylogenetic analysis. Traditional local computing resources are no longer sufficient, and the CIPRES Science Gateway was developed to address this need by offering access to the fastest available community codes for phylogenetic inference. The gateway was designed to meet the needs of the systematics community by providing a scalable, sustainable resource that allows users to run jobs requiring significant computational power. It includes features such as simple browser-based access to community tree inference codes, storage of uploaded files and job records, tailored interfaces for different user expertise levels, and easy access to the fastest available codes on scalable resources. The gateway also allows for the addition of new tools and updates to existing ones, and it minimizes job loss due to system errors or file format issues. The CIPRES Science Gateway was implemented using a new architecture called the Workbench Framework (WF), which allows for the deployment of analytical jobs and database searches on various computational resources. The gateway supports access to a wide range of computational resources, including TeraGrid resources, and provides a flexible and scalable solution for phylogenetic analysis. The gateway has been widely adopted, with over 1800 unique users running jobs that required 2.5 million Service Units since its release in December 2009. The gateway has proven to be a critical resource for the systematics community, enabling researchers to perform complex phylogenetic analyses that would be impractical with local computing resources. However, the increasing demand for computational resources has raised the need for effective management strategies to ensure fair access and sustainability. The gateway has implemented policies to manage resource usage, including limiting access for high-consumption users and requiring personal allocations for those who exceed certain thresholds. These measures ensure that the gateway remains a sustainable and accessible resource for the systematics community.