The paper describes the development and implementation of the CIPRES Science Gateway, a web portal designed to provide researchers with access to powerful computational resources for inferring phylogenetic relationships. The gateway addresses the challenge of analyzing large amounts of DNA sequence data, which requires significant computational resources. The CIPRES Science Gateway offers community tree inference tools such as GARLI, RAxML, PAUP, and MrBayes, and provides access to scalable high-performance computing resources on the TeraGrid. The portal has been successful, with over 1800 unique users running jobs that required 2.5 million Service Units since its release in December 2009. The paper outlines the architecture and implementation of the CIPRES Science Gateway, including its scalability, job submission and monitoring mechanisms, and management of portal usage. Future work focuses on improving resource efficiency, simplifying the user experience, and addressing issues related to job loss due to file format errors and resource scheduling. The CIPRES Science Gateway has significantly benefited the research community, but managing the increasing demand for computational resources remains a challenge.The paper describes the development and implementation of the CIPRES Science Gateway, a web portal designed to provide researchers with access to powerful computational resources for inferring phylogenetic relationships. The gateway addresses the challenge of analyzing large amounts of DNA sequence data, which requires significant computational resources. The CIPRES Science Gateway offers community tree inference tools such as GARLI, RAxML, PAUP, and MrBayes, and provides access to scalable high-performance computing resources on the TeraGrid. The portal has been successful, with over 1800 unique users running jobs that required 2.5 million Service Units since its release in December 2009. The paper outlines the architecture and implementation of the CIPRES Science Gateway, including its scalability, job submission and monitoring mechanisms, and management of portal usage. Future work focuses on improving resource efficiency, simplifying the user experience, and addressing issues related to job loss due to file format errors and resource scheduling. The CIPRES Science Gateway has significantly benefited the research community, but managing the increasing demand for computational resources remains a challenge.