RNA methylation, a critical posttranscriptional modification, plays a significant role in RNA metabolism and gene expression, influencing cellular functions and disease progression. This review highlights the fundamental characteristics of RNA methylation and its impact on RNA metabolism and gene expression. It discusses the intricate relationship between RNA methylation, cancer metabolic reprogramming, and immunity, using cancer metabolic reprogramming as a framework to explore the specific roles and mechanisms of RNA methylation in cancer progression. The review also explores the potential of targeting RNA methylation regulators as a novel approach for cancer therapy. By underscoring the complex mechanisms by which RNA methylation contributes to cancer progression, this review provides a foundation for further research and potential clinical applications.RNA methylation, a critical posttranscriptional modification, plays a significant role in RNA metabolism and gene expression, influencing cellular functions and disease progression. This review highlights the fundamental characteristics of RNA methylation and its impact on RNA metabolism and gene expression. It discusses the intricate relationship between RNA methylation, cancer metabolic reprogramming, and immunity, using cancer metabolic reprogramming as a framework to explore the specific roles and mechanisms of RNA methylation in cancer progression. The review also explores the potential of targeting RNA methylation regulators as a novel approach for cancer therapy. By underscoring the complex mechanisms by which RNA methylation contributes to cancer progression, this review provides a foundation for further research and potential clinical applications.