The chapter discusses the growing interest in cross-cultural research methods, particularly in abnormal and clinical psychology, driven by societal changes such as globalization and migration. It highlights the challenges in adapting research and theories to accommodate cultural variations and the need for culturally informed policies and practices. The chapter explores the universality and cultural specificity of clinical syndromes, emphasizing the importance of understanding the relationship between cultural factors and psychopathology. It also addresses the concept of acculturation, which involves the changes in cultural patterns due to continuous cross-cultural encounters, and its impact on mental health. The chapter further discusses the need for culturally accommodated assessment and psychotherapy, including the development of empirically supported therapies that are culturally sensitive. It emphasizes the importance of cultural accommodation criteria, such as culturally relevant definitions of abnormal behavior and culturally accepted norms, to reduce cultural distance and improve treatment effectiveness. The chapter concludes by highlighting the ongoing research agenda to establish culturally accommodated psychotherapies and the need for culturally sensitive assessments to ensure equitable access to mental health care.The chapter discusses the growing interest in cross-cultural research methods, particularly in abnormal and clinical psychology, driven by societal changes such as globalization and migration. It highlights the challenges in adapting research and theories to accommodate cultural variations and the need for culturally informed policies and practices. The chapter explores the universality and cultural specificity of clinical syndromes, emphasizing the importance of understanding the relationship between cultural factors and psychopathology. It also addresses the concept of acculturation, which involves the changes in cultural patterns due to continuous cross-cultural encounters, and its impact on mental health. The chapter further discusses the need for culturally accommodated assessment and psychotherapy, including the development of empirically supported therapies that are culturally sensitive. It emphasizes the importance of cultural accommodation criteria, such as culturally relevant definitions of abnormal behavior and culturally accepted norms, to reduce cultural distance and improve treatment effectiveness. The chapter concludes by highlighting the ongoing research agenda to establish culturally accommodated psychotherapies and the need for culturally sensitive assessments to ensure equitable access to mental health care.