This systematic review evaluates the potential of curcumin in addressing age-related disorders, focusing on its impact on cognitive function, neurodegeneration, and muscle health in older adults. Curcumin, a natural compound with potent antioxidant and anti-inflammatory properties, has shown promise in mitigating age-related processes such as inflammation, oxidative stress, and mitochondrial dysfunction. The review synthesizes current evidence from 15 clinical trials, highlighting curcumin’s potential as a multifaceted therapeutic agent. The findings suggest that curcumin could offer a natural and effective approach to enhancing the quality of life of aging individuals. However, gaps in understanding its precise mechanisms of action and optimal dosages for different conditions necessitate further research. The review also emphasizes the need for well-designed clinical trials to validate curcumin’s therapeutic potential and optimize its use in personalized medicine approaches for age-related conditions. Curcumin’s mechanisms of action include its ability to modulate inflammatory pathways, reduce oxidative stress, and improve mitochondrial function, which are critical in combating age-related disorders. The study underscores the importance of further investigation to fully harness curcumin’s potential in promoting healthy aging.This systematic review evaluates the potential of curcumin in addressing age-related disorders, focusing on its impact on cognitive function, neurodegeneration, and muscle health in older adults. Curcumin, a natural compound with potent antioxidant and anti-inflammatory properties, has shown promise in mitigating age-related processes such as inflammation, oxidative stress, and mitochondrial dysfunction. The review synthesizes current evidence from 15 clinical trials, highlighting curcumin’s potential as a multifaceted therapeutic agent. The findings suggest that curcumin could offer a natural and effective approach to enhancing the quality of life of aging individuals. However, gaps in understanding its precise mechanisms of action and optimal dosages for different conditions necessitate further research. The review also emphasizes the need for well-designed clinical trials to validate curcumin’s therapeutic potential and optimize its use in personalized medicine approaches for age-related conditions. Curcumin’s mechanisms of action include its ability to modulate inflammatory pathways, reduce oxidative stress, and improve mitochondrial function, which are critical in combating age-related disorders. The study underscores the importance of further investigation to fully harness curcumin’s potential in promoting healthy aging.