Cigarette smoking among U.S. adults declined from 20.9% in 2005 to 17.8% in 2013, with daily smokers decreasing from 16.9% to 13.7%. Among daily smokers, the average number of cigarettes smoked per day decreased from 16.7 to 14.2. Smoking prevalence was higher among males, younger adults, multiracial individuals, American Indians/Alaska Natives, those with less education, those living below the poverty level, those in the South or Midwest, those with disabilities, and LGB adults. Cigarette smoking remains particularly high among these subpopulations. Proven interventions, including tobacco price increases, smoke-free policies, anti-smoking campaigns, and cessation assistance, are critical to reducing smoking and its health impacts. The National Health Interview Survey (NHIS) data showed that smoking prevalence was highest among adults reporting multiple races and American Indians/Alaska Natives, and lowest among non-Hispanic Asians. Smoking prevalence was higher among LGB adults (26.6%) than straight adults (17.6%). The proportion of daily smokers who smoked 20–29 cigarettes per day declined from 34.9% to 29.3%, while those smoking ≥30 cigarettes per day declined from 12.7% to 7.1%. Despite progress, approximately 42.1 million adults still smoke, highlighting the need for continued evidence-based interventions. The findings underscore the importance of implementing effective public health strategies to reduce smoking-related disparities and meet the Healthy People 2020 target. The report also notes limitations, including self-reported smoking status, exclusion of institutionalized populations, potential nonresponse bias, and lack of gender identity data. The findings emphasize the need for sustained, comprehensive tobacco control programs to reduce the health and economic burden of tobacco use.Cigarette smoking among U.S. adults declined from 20.9% in 2005 to 17.8% in 2013, with daily smokers decreasing from 16.9% to 13.7%. Among daily smokers, the average number of cigarettes smoked per day decreased from 16.7 to 14.2. Smoking prevalence was higher among males, younger adults, multiracial individuals, American Indians/Alaska Natives, those with less education, those living below the poverty level, those in the South or Midwest, those with disabilities, and LGB adults. Cigarette smoking remains particularly high among these subpopulations. Proven interventions, including tobacco price increases, smoke-free policies, anti-smoking campaigns, and cessation assistance, are critical to reducing smoking and its health impacts. The National Health Interview Survey (NHIS) data showed that smoking prevalence was highest among adults reporting multiple races and American Indians/Alaska Natives, and lowest among non-Hispanic Asians. Smoking prevalence was higher among LGB adults (26.6%) than straight adults (17.6%). The proportion of daily smokers who smoked 20–29 cigarettes per day declined from 34.9% to 29.3%, while those smoking ≥30 cigarettes per day declined from 12.7% to 7.1%. Despite progress, approximately 42.1 million adults still smoke, highlighting the need for continued evidence-based interventions. The findings underscore the importance of implementing effective public health strategies to reduce smoking-related disparities and meet the Healthy People 2020 target. The report also notes limitations, including self-reported smoking status, exclusion of institutionalized populations, potential nonresponse bias, and lack of gender identity data. The findings emphasize the need for sustained, comprehensive tobacco control programs to reduce the health and economic burden of tobacco use.