In 2016, the prevalence of current cigarette smoking among U.S. adults was 15.5%, a significant decline from 2005 (20.9%) but no change since 2015 (15.1%). The prevalence was higher among males, adults aged 25–64, American Indian/Alaska Natives, those with a GED, those living below the poverty level, and those in the Midwest and South. The proportion of ever smokers who quit smoking increased from 50.8% to 59.0% between 2005 and 2016. The overall quit ratio increased from 50.8% in 2005 to 59.0% in 2016. The largest increase in quit ratios occurred among adults aged 25–44 years. Despite the decline in smoking prevalence, disparities in smoking rates persisted among different sociodemographic groups. Proven population-based interventions, including tobacco price increases, smoke-free laws, anti-tobacco campaigns, and access to cessation counseling and medications, are critical to reducing smoking and related health issues. The findings highlight the need for sustained implementation of these interventions to continue reducing adult smoking rates. The study also noted limitations, including self-reported smoking status, lack of data on institutionalized populations, potential nonresponse bias, and the possibility of differences between surveys. The report emphasizes the importance of targeted interventions to address subpopulations with the highest smoking rates.In 2016, the prevalence of current cigarette smoking among U.S. adults was 15.5%, a significant decline from 2005 (20.9%) but no change since 2015 (15.1%). The prevalence was higher among males, adults aged 25–64, American Indian/Alaska Natives, those with a GED, those living below the poverty level, and those in the Midwest and South. The proportion of ever smokers who quit smoking increased from 50.8% to 59.0% between 2005 and 2016. The overall quit ratio increased from 50.8% in 2005 to 59.0% in 2016. The largest increase in quit ratios occurred among adults aged 25–44 years. Despite the decline in smoking prevalence, disparities in smoking rates persisted among different sociodemographic groups. Proven population-based interventions, including tobacco price increases, smoke-free laws, anti-tobacco campaigns, and access to cessation counseling and medications, are critical to reducing smoking and related health issues. The findings highlight the need for sustained implementation of these interventions to continue reducing adult smoking rates. The study also noted limitations, including self-reported smoking status, lack of data on institutionalized populations, potential nonresponse bias, and the possibility of differences between surveys. The report emphasizes the importance of targeted interventions to address subpopulations with the highest smoking rates.