The Great American Smokeout, an annual event organized by the American Cancer Society, encourages smokers to quit on November 17, 2016. Despite a significant reduction in cigarette smoking among U.S. adults over the past 50 years, smoking remains the leading preventable cause of disease, disability, and death in the United States. About two-thirds of adult smokers want to quit, and many make attempts each year, but effective support through counseling and medications can triple the chances of quitting success. The CDC provides resources and support for quitting, including a toll-free hotline and online campaigns. The report also highlights disparities in smoking prevalence, such as higher rates among males, younger adults, American Indian/Alaska Natives, those with lower education levels, and those living below the poverty level. Population-based interventions, including tobacco price increases, smoke-free laws, and access to cessation services, are crucial for reducing smoking-related health issues.The Great American Smokeout, an annual event organized by the American Cancer Society, encourages smokers to quit on November 17, 2016. Despite a significant reduction in cigarette smoking among U.S. adults over the past 50 years, smoking remains the leading preventable cause of disease, disability, and death in the United States. About two-thirds of adult smokers want to quit, and many make attempts each year, but effective support through counseling and medications can triple the chances of quitting success. The CDC provides resources and support for quitting, including a toll-free hotline and online campaigns. The report also highlights disparities in smoking prevalence, such as higher rates among males, younger adults, American Indian/Alaska Natives, those with lower education levels, and those living below the poverty level. Population-based interventions, including tobacco price increases, smoke-free laws, and access to cessation services, are crucial for reducing smoking-related health issues.