Severe Fever with Thrombocytopenia Syndrome Virus (SFTSV) is an emerging tick-borne virus causing a hemorrhagic fever with a high case fatality rate (CFR) of up to 27%. The virus is endemic in East Asia and has recently spread to over 20 states in the United States, posing a growing public health concern. Currently, there are no targeted antiviral therapies or licensed vaccines available. The development of a sophisticated vaccine is crucial to protect the elderly population, who are most at risk due to age-dependent pathogenesis and disease outcomes. Recent research has explored various vaccine platforms, including live-attenuated, DNA, whole inactivated, viral vector, protein subunit, and mRNA vaccines. This review outlines the current progress in SFTSV vaccine development, highlighting the strengths and weaknesses of each platform. It also discusses animal models used to study vaccine efficacy and suggests future directions to enhance the safety and efficacy of these vaccines for clinical application. The review emphasizes the need for comprehensive evaluation of immunization protocols and the effectiveness and safety of vaccine candidates, particularly among the elderly population.Severe Fever with Thrombocytopenia Syndrome Virus (SFTSV) is an emerging tick-borne virus causing a hemorrhagic fever with a high case fatality rate (CFR) of up to 27%. The virus is endemic in East Asia and has recently spread to over 20 states in the United States, posing a growing public health concern. Currently, there are no targeted antiviral therapies or licensed vaccines available. The development of a sophisticated vaccine is crucial to protect the elderly population, who are most at risk due to age-dependent pathogenesis and disease outcomes. Recent research has explored various vaccine platforms, including live-attenuated, DNA, whole inactivated, viral vector, protein subunit, and mRNA vaccines. This review outlines the current progress in SFTSV vaccine development, highlighting the strengths and weaknesses of each platform. It also discusses animal models used to study vaccine efficacy and suggests future directions to enhance the safety and efficacy of these vaccines for clinical application. The review emphasizes the need for comprehensive evaluation of immunization protocols and the effectiveness and safety of vaccine candidates, particularly among the elderly population.