This mini-review discusses current treatment options for leptospirosis, a severe zoonotic infection caused by Leptospira species. The review highlights antibiotic therapy, including doxycycline for mild cases and penicillin for severe cases, as well as the role of probiotics in modulating gut microbiota. Novel treatments, such as bacteriophages and new compounds, are also explored. The review emphasizes the importance of early diagnosis and treatment, as well as the need for further research into vaccine development and alternative therapies. It also discusses the challenges of leptospirosis transmission, particularly in tropical regions, and the impact of environmental and socioeconomic factors on its prevalence. The review concludes that effective treatment strategies for leptospirosis include antibiotic therapy, probiotics, and emerging treatments, with a focus on improving outcomes for severe cases. The review also highlights the need for further research into the pathogenesis of leptospirosis and the development of more effective vaccines and treatments.This mini-review discusses current treatment options for leptospirosis, a severe zoonotic infection caused by Leptospira species. The review highlights antibiotic therapy, including doxycycline for mild cases and penicillin for severe cases, as well as the role of probiotics in modulating gut microbiota. Novel treatments, such as bacteriophages and new compounds, are also explored. The review emphasizes the importance of early diagnosis and treatment, as well as the need for further research into vaccine development and alternative therapies. It also discusses the challenges of leptospirosis transmission, particularly in tropical regions, and the impact of environmental and socioeconomic factors on its prevalence. The review concludes that effective treatment strategies for leptospirosis include antibiotic therapy, probiotics, and emerging treatments, with a focus on improving outcomes for severe cases. The review also highlights the need for further research into the pathogenesis of leptospirosis and the development of more effective vaccines and treatments.