Cytokine storm in COVID-19 is a severe immune response characterized by excessive production of pro-inflammatory cytokines, such as IL-6, leading to tissue damage and poor prognosis. This review summarizes the clinical, immunological, and pathological features of cytokine storm in COVID-19 and discusses potential treatment strategies. SARS-CoV-2 induces a high level of IL-6 and lymphocyte exhaustion, contributing to the cytokine storm. Current evidence suggests that IL-6 inhibitors like tocilizumab (TCZ) are effective and safe for treating cytokine storm in COVID-19. Other potential treatments include corticosteroids, PD-1/PD-L1 checkpoint inhibitors, cytokine-adsorption devices, intravenous immunoglobulin, and antimalarial agents. However, the efficacy and safety of these treatments require further clinical validation. The review also highlights the similarities between cytokine storm in COVID-19 and other coronaviruses like SARS and MERS, and discusses the role of immune cell dysregulation in the pathogenesis of the disease. The study emphasizes the need for standardized criteria to identify cytokine storm in COVID-19 and further research to evaluate the effectiveness of various treatments.Cytokine storm in COVID-19 is a severe immune response characterized by excessive production of pro-inflammatory cytokines, such as IL-6, leading to tissue damage and poor prognosis. This review summarizes the clinical, immunological, and pathological features of cytokine storm in COVID-19 and discusses potential treatment strategies. SARS-CoV-2 induces a high level of IL-6 and lymphocyte exhaustion, contributing to the cytokine storm. Current evidence suggests that IL-6 inhibitors like tocilizumab (TCZ) are effective and safe for treating cytokine storm in COVID-19. Other potential treatments include corticosteroids, PD-1/PD-L1 checkpoint inhibitors, cytokine-adsorption devices, intravenous immunoglobulin, and antimalarial agents. However, the efficacy and safety of these treatments require further clinical validation. The review also highlights the similarities between cytokine storm in COVID-19 and other coronaviruses like SARS and MERS, and discusses the role of immune cell dysregulation in the pathogenesis of the disease. The study emphasizes the need for standardized criteria to identify cytokine storm in COVID-19 and further research to evaluate the effectiveness of various treatments.