Cytoscape 2.8 introduces two significant new features: Custom Node Graphics and Attribute Equations, enhancing its capabilities for data integration and network visualization. Custom Node Graphics allow users to map images onto nodes, including dynamically generated or remote images, providing rich and flexible visualizations. Attribute Equations enable users to perform spreadsheet-like calculations within the Cytoscape Attribute Browser, allowing for complex data transformations and manipulations. These features together provide a powerful mechanism for integrating and visualizing complex datasets, making Cytoscape a more versatile tool for biological network analysis. The article also includes illustrative examples demonstrating the integration of custom graphics with equations, such as displaying protein structures and time course data in network visualizations.Cytoscape 2.8 introduces two significant new features: Custom Node Graphics and Attribute Equations, enhancing its capabilities for data integration and network visualization. Custom Node Graphics allow users to map images onto nodes, including dynamically generated or remote images, providing rich and flexible visualizations. Attribute Equations enable users to perform spreadsheet-like calculations within the Cytoscape Attribute Browser, allowing for complex data transformations and manipulations. These features together provide a powerful mechanism for integrating and visualizing complex datasets, making Cytoscape a more versatile tool for biological network analysis. The article also includes illustrative examples demonstrating the integration of custom graphics with equations, such as displaying protein structures and time course data in network visualizations.