Cytoscape StringApp: Network Analysis and Visualization of Proteomics Data

Cytoscape StringApp: Network Analysis and Visualization of Proteomics Data

2019 February 01 | Nadezhda T. Doncheva, John H. Morris, Jan Gorodkin, Lars J. Jensen
The Cytoscape StringApp is a tool that integrates the STRING database with Cytoscape for network analysis and visualization of proteomics data. STRING provides protein interaction networks for over 2000 organisms, including both experimental and predicted interactions. However, its web interface is limited for large networks. Cytoscape, on the other hand, is well-suited for large networks and offers greater flexibility in analysis and visualization. The StringApp bridges these two tools, allowing users to import STRING networks into Cytoscape while retaining the appearance and features of STRING. It also integrates data from associated databases, such as small molecule interactions, subcellular localization, and drug target information. The app supports various query types, including protein lists, diseases, and PubMed queries, and enables users to perform complex network analysis and visualization tasks through the Cytoscape interface. The StringApp also includes algorithms for network expansion and PubMed query-based network retrieval, which help in identifying relevant proteins and interactions. Additionally, it provides functional enrichment analysis, allowing users to explore enriched terms and visualize them on the network. The app is freely available from the Cytoscape app store and is designed to facilitate the integration of proteomics data with existing biological knowledge. The StringApp supports a wide range of features, including clustering, visualization, and data mapping, making it a powerful tool for analyzing proteomics data. It is particularly useful for identifying druggable targets and understanding disease-related protein interactions. The app is also compatible with automation features, allowing scripted execution of analyses within Cytoscape. Overall, the StringApp provides a comprehensive solution for network analysis and visualization of proteomics data, combining the strengths of STRING and Cytoscape.The Cytoscape StringApp is a tool that integrates the STRING database with Cytoscape for network analysis and visualization of proteomics data. STRING provides protein interaction networks for over 2000 organisms, including both experimental and predicted interactions. However, its web interface is limited for large networks. Cytoscape, on the other hand, is well-suited for large networks and offers greater flexibility in analysis and visualization. The StringApp bridges these two tools, allowing users to import STRING networks into Cytoscape while retaining the appearance and features of STRING. It also integrates data from associated databases, such as small molecule interactions, subcellular localization, and drug target information. The app supports various query types, including protein lists, diseases, and PubMed queries, and enables users to perform complex network analysis and visualization tasks through the Cytoscape interface. The StringApp also includes algorithms for network expansion and PubMed query-based network retrieval, which help in identifying relevant proteins and interactions. Additionally, it provides functional enrichment analysis, allowing users to explore enriched terms and visualize them on the network. The app is freely available from the Cytoscape app store and is designed to facilitate the integration of proteomics data with existing biological knowledge. The StringApp supports a wide range of features, including clustering, visualization, and data mapping, making it a powerful tool for analyzing proteomics data. It is particularly useful for identifying druggable targets and understanding disease-related protein interactions. The app is also compatible with automation features, allowing scripted execution of analyses within Cytoscape. Overall, the StringApp provides a comprehensive solution for network analysis and visualization of proteomics data, combining the strengths of STRING and Cytoscape.
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