This paper demonstrates the use of DNA origami to create chiral plasmonic nanostructures with tailored optical responses. The authors arranged metal nanoparticles (NPs) into nanoscale helices with a spatial accuracy of 2 nm using the DNA origami method. These helical structures exhibit significant circular dichroism (CD) and optical rotary dispersion (ORD) in the visible range, which arise from collective plasmon-plasmon interactions. The optical response can be tuned by changing the composition of the metal nanoparticles, and the helices can be oriented to switch between left- and right-handed configurations. The study highlights the potential of DNA self-assembly for creating complex, optically active materials with precise control over their properties, which could have applications in metamaterials, cloaking, and perfect lenses.This paper demonstrates the use of DNA origami to create chiral plasmonic nanostructures with tailored optical responses. The authors arranged metal nanoparticles (NPs) into nanoscale helices with a spatial accuracy of 2 nm using the DNA origami method. These helical structures exhibit significant circular dichroism (CD) and optical rotary dispersion (ORD) in the visible range, which arise from collective plasmon-plasmon interactions. The optical response can be tuned by changing the composition of the metal nanoparticles, and the helices can be oriented to switch between left- and right-handed configurations. The study highlights the potential of DNA self-assembly for creating complex, optically active materials with precise control over their properties, which could have applications in metamaterials, cloaking, and perfect lenses.