The National Comorbidity Survey Replication (NCS-R) estimated the prevalence of DSM-IV personality disorders (PDs) in the U.S. general population. Using a sample of 5,692 adults, the study found that 5.7% had Cluster A PDs, 1.5% Cluster B, and 6.0% Cluster C, with 9.1% having any PD. These PDs were significantly comorbid with Axis I disorders, and most functional impairment was attributed to these comorbidities. The study suggests that the public health impact of PDs is mainly through their association with Axis I disorders rather than directly on functioning. PDs were also associated with higher treatment rates, particularly for Cluster B. The findings highlight the high comorbidity between PDs and Axis I disorders, and the need for further research to understand the role of PDs in the broader context of mental health. The study underscores the importance of considering PDs in the broader mental health landscape and the need for more comprehensive assessments of their impact. The results indicate that PDs are relatively common and have significant implications for mental health, particularly in relation to Axis I disorders. The study also notes that the prevalence of PDs is slightly lower than direct estimates from the clinical reappraisal sample, but the MI estimates are more precise. The study concludes that the DSM-IV classification of PDs as separate from Axis I disorders may be arbitrary, given the high comorbidity observed. The findings suggest that PDs are strongly associated with Axis I disorders and that their impact on functioning is largely mediated through these comorbidities. The study also highlights the need for further research to understand the role of PDs in the broader mental health context.The National Comorbidity Survey Replication (NCS-R) estimated the prevalence of DSM-IV personality disorders (PDs) in the U.S. general population. Using a sample of 5,692 adults, the study found that 5.7% had Cluster A PDs, 1.5% Cluster B, and 6.0% Cluster C, with 9.1% having any PD. These PDs were significantly comorbid with Axis I disorders, and most functional impairment was attributed to these comorbidities. The study suggests that the public health impact of PDs is mainly through their association with Axis I disorders rather than directly on functioning. PDs were also associated with higher treatment rates, particularly for Cluster B. The findings highlight the high comorbidity between PDs and Axis I disorders, and the need for further research to understand the role of PDs in the broader context of mental health. The study underscores the importance of considering PDs in the broader mental health landscape and the need for more comprehensive assessments of their impact. The results indicate that PDs are relatively common and have significant implications for mental health, particularly in relation to Axis I disorders. The study also notes that the prevalence of PDs is slightly lower than direct estimates from the clinical reappraisal sample, but the MI estimates are more precise. The study concludes that the DSM-IV classification of PDs as separate from Axis I disorders may be arbitrary, given the high comorbidity observed. The findings suggest that PDs are strongly associated with Axis I disorders and that their impact on functioning is largely mediated through these comorbidities. The study also highlights the need for further research to understand the role of PDs in the broader mental health context.