The Danish National Prescription Registry (NPR) is a comprehensive data resource that provides individual-level data on prescriptions filled at Danish community pharmacies since 1995. It is a key resource for pharmacoepidemiological research, offering detailed information on prescriptions, including patient, drug, prescriber, and dispensing pharmacy details. The NPR is linked to other Danish registries via the Civil Personal Register (CPR) number, enabling population-based studies. Data are collected through electronic dispensing systems, ensuring accuracy and completeness. The registry includes 46 variables, such as prescription date, drug composition, and package size, and provides data on drug use in the context of the Danish healthcare system, where GPs are the primary prescribers. The NPR is used to study drug utilization, treatment quality, and long-term drug effects. However, it lacks data on prescription indications, duration, and dosage, requiring researchers to make assumptions. The NPR is accessible through anonymized data from Statistics Denmark and the Danish Health Data Authority, with data not transferable outside these platforms. It is compared to other Nordic prescription registries, with strengths including nationwide coverage and linkage to other registries. The NPR is subject to data protection laws, and access requires approval. The registry has been used in numerous studies, including those on drug safety, cancer associations, and drug use in specific populations. Despite its strengths, the NPR has limitations, such as lack of data on over-the-counter drugs and potential misclassification due to data gaps. Overall, the NPR is a valuable resource for pharmacoepidemiological research in Denmark.The Danish National Prescription Registry (NPR) is a comprehensive data resource that provides individual-level data on prescriptions filled at Danish community pharmacies since 1995. It is a key resource for pharmacoepidemiological research, offering detailed information on prescriptions, including patient, drug, prescriber, and dispensing pharmacy details. The NPR is linked to other Danish registries via the Civil Personal Register (CPR) number, enabling population-based studies. Data are collected through electronic dispensing systems, ensuring accuracy and completeness. The registry includes 46 variables, such as prescription date, drug composition, and package size, and provides data on drug use in the context of the Danish healthcare system, where GPs are the primary prescribers. The NPR is used to study drug utilization, treatment quality, and long-term drug effects. However, it lacks data on prescription indications, duration, and dosage, requiring researchers to make assumptions. The NPR is accessible through anonymized data from Statistics Denmark and the Danish Health Data Authority, with data not transferable outside these platforms. It is compared to other Nordic prescription registries, with strengths including nationwide coverage and linkage to other registries. The NPR is subject to data protection laws, and access requires approval. The registry has been used in numerous studies, including those on drug safety, cancer associations, and drug use in specific populations. Despite its strengths, the NPR has limitations, such as lack of data on over-the-counter drugs and potential misclassification due to data gaps. Overall, the NPR is a valuable resource for pharmacoepidemiological research in Denmark.