This article presents a de-duplication method for EndNote, a reference manager, to efficiently and accurately remove duplicate records from database searches in systematic reviews. The method involves three stages: configuring EndNote settings to display page numbers, importing and exporting references in an adapted format, and detecting and removing duplicates using specific fields. The method relies on page numbers, which are often used as unique identifiers in scientific journals, but can vary in format between databases. To address this, the authors customized EndNote styles and filters to expand abbreviated page numbers and import corrected page numbers. The method is described in detail for EndNote, including steps for field settings, importing references, and de-duplication. The method is more systematic, rigorous, and reproducible than existing methods, and reduces the time and error rate associated with manual screening. However, the method is specific to EndNote and may not work in other software like Reference Manager. The authors also note that the method is complex and requires some learning, but becomes easier with practice. The method is applicable to the most recent version of EndNote for Windows, version X7, and also works in earlier versions with some modifications. The method is effective in reducing the number of references that need manual assessment, as it uses page numbers to identify duplicates. The authors also note that the method is limited by the format of page numbers and journal titles in different databases, and that standardization would improve its effectiveness. The method is recommended for use in systematic reviews to improve the efficiency and accuracy of de-duplication.This article presents a de-duplication method for EndNote, a reference manager, to efficiently and accurately remove duplicate records from database searches in systematic reviews. The method involves three stages: configuring EndNote settings to display page numbers, importing and exporting references in an adapted format, and detecting and removing duplicates using specific fields. The method relies on page numbers, which are often used as unique identifiers in scientific journals, but can vary in format between databases. To address this, the authors customized EndNote styles and filters to expand abbreviated page numbers and import corrected page numbers. The method is described in detail for EndNote, including steps for field settings, importing references, and de-duplication. The method is more systematic, rigorous, and reproducible than existing methods, and reduces the time and error rate associated with manual screening. However, the method is specific to EndNote and may not work in other software like Reference Manager. The authors also note that the method is complex and requires some learning, but becomes easier with practice. The method is applicable to the most recent version of EndNote for Windows, version X7, and also works in earlier versions with some modifications. The method is effective in reducing the number of references that need manual assessment, as it uses page numbers to identify duplicates. The authors also note that the method is limited by the format of page numbers and journal titles in different databases, and that standardization would improve its effectiveness. The method is recommended for use in systematic reviews to improve the efficiency and accuracy of de-duplication.