The article presents a method for de-duplication of database search results in EndNote, a popular reference management software, to reduce the workload associated with screening titles and abstracts for systematic reviews. The method consists of three stages: changing settings for displayed fields and installing custom filters and export formats, importing and exporting references in an adapted format, and detecting and removing duplicates. The authors emphasize the importance of showing page numbers in the library window and customizing an EndNote style to expand abbreviated page numbers. They also provide detailed steps for importing references from PubMed, MEDLINE, and the Cochrane Library, and for de-duplication. The method is more systematic, rigorous, and reproducible compared to existing methods, significantly reducing the time spent on de-duplication and the error rate. However, it is tailored for EndNote and may not work as well with other software like Reference Manager. The authors suggest that simplifying the method could increase the workload, but frequent use can make librarian-mediated de-duplication services faster and less error-prone.The article presents a method for de-duplication of database search results in EndNote, a popular reference management software, to reduce the workload associated with screening titles and abstracts for systematic reviews. The method consists of three stages: changing settings for displayed fields and installing custom filters and export formats, importing and exporting references in an adapted format, and detecting and removing duplicates. The authors emphasize the importance of showing page numbers in the library window and customizing an EndNote style to expand abbreviated page numbers. They also provide detailed steps for importing references from PubMed, MEDLINE, and the Cochrane Library, and for de-duplication. The method is more systematic, rigorous, and reproducible compared to existing methods, significantly reducing the time spent on de-duplication and the error rate. However, it is tailored for EndNote and may not work as well with other software like Reference Manager. The authors suggest that simplifying the method could increase the workload, but frequent use can make librarian-mediated de-duplication services faster and less error-prone.