From 2016 to 2021, the average annual number of deaths from excessive alcohol use in the United States increased by 29.3%, from 137,927 to 178,307. Age-standardized death rates rose from 38.1 to 47.6 per 100,000 population. Among males, deaths increased by 26.8%, from 94,362 to 119,606, while among females, the increase was 34.7%, from 43,565 to 58,701. These increases were particularly notable between 2019 and 2020, coinciding with the onset of the COVID-19 pandemic. The study used the CDC's Alcohol-Related Disease Impact (ARDI) application to estimate deaths from 58 alcohol-related causes, including both fully and partially alcohol-attributable conditions. Fully alcohol-attributable conditions accounted for 51,665 deaths in 2020–2021, a 46.2% increase compared to 2016–2017. Partially alcohol-attributable causes accounted for 126,642 deaths, a 23.5% increase. The study highlights the need for evidence-based policies to reduce alcohol availability and increase its price, which could help reduce excessive alcohol use and related deaths. The findings underscore the importance of addressing both fully and partially alcohol-attributable causes to better understand the harms of excessive drinking. The study also notes that increases in alcohol availability and the pandemic's impact on healthcare access may have contributed to the rise in alcohol-related deaths. Limitations include potential underestimation of alcohol-attributable deaths due to data limitations. The report emphasizes the need for public health strategies to address alcohol use and its associated risks.From 2016 to 2021, the average annual number of deaths from excessive alcohol use in the United States increased by 29.3%, from 137,927 to 178,307. Age-standardized death rates rose from 38.1 to 47.6 per 100,000 population. Among males, deaths increased by 26.8%, from 94,362 to 119,606, while among females, the increase was 34.7%, from 43,565 to 58,701. These increases were particularly notable between 2019 and 2020, coinciding with the onset of the COVID-19 pandemic. The study used the CDC's Alcohol-Related Disease Impact (ARDI) application to estimate deaths from 58 alcohol-related causes, including both fully and partially alcohol-attributable conditions. Fully alcohol-attributable conditions accounted for 51,665 deaths in 2020–2021, a 46.2% increase compared to 2016–2017. Partially alcohol-attributable causes accounted for 126,642 deaths, a 23.5% increase. The study highlights the need for evidence-based policies to reduce alcohol availability and increase its price, which could help reduce excessive alcohol use and related deaths. The findings underscore the importance of addressing both fully and partially alcohol-attributable causes to better understand the harms of excessive drinking. The study also notes that increases in alcohol availability and the pandemic's impact on healthcare access may have contributed to the rise in alcohol-related deaths. Limitations include potential underestimation of alcohol-attributable deaths due to data limitations. The report emphasizes the need for public health strategies to address alcohol use and its associated risks.