This article reviews the role of nickel (Ni)-based catalysts in electrochemical organic oxidation reactions (OORs), highlighting their significance in sustainable and cost-effective oxidation of organic compounds. The review discusses the electrochemical oxidation of various organic molecules, including alcohols, aldehydes, amines, and biomass-derived feedstocks like hydroxymethylfurfural (HMF) and glycerol. It emphasizes the unique redox activity and chemical nature of Ni, which enable efficient and selective oxidation. The review explores how strategic modifications, such as the use of foreign metals, intercalating species, and defects, can enhance the performance of Ni-based catalysts. It also delves into the active species involved in different reaction environments and the reaction mechanisms, including phase changes in the catalyst. The review identifies the limitations of current approaches and outlines future directions for improving OORs. The study discusses the mechanism of organic oxidation, focusing on the effects of reactant hydrophilicity, and the dynamic behavior of Ni valence states during OORs. It also examines the oxidation states of Ni in OORs, using techniques like XANES, XPS, and Raman spectroscopy, to determine their role in catalytic activity. The review highlights the importance of understanding the oxidation state of Ni in Ni-based catalysts for optimizing OORs and improving their efficiency and selectivity. The study also discusses the impact of phase changes on the selectivity and efficiency of product formation in OORs, emphasizing the need for a thorough understanding of the active catalyst phase during long-term OOR processes. The review concludes that Ni-based catalysts, with their dynamic redox behavior and ability to switch oxidation states, play a crucial role in facilitating OORs and enhancing their performance.This article reviews the role of nickel (Ni)-based catalysts in electrochemical organic oxidation reactions (OORs), highlighting their significance in sustainable and cost-effective oxidation of organic compounds. The review discusses the electrochemical oxidation of various organic molecules, including alcohols, aldehydes, amines, and biomass-derived feedstocks like hydroxymethylfurfural (HMF) and glycerol. It emphasizes the unique redox activity and chemical nature of Ni, which enable efficient and selective oxidation. The review explores how strategic modifications, such as the use of foreign metals, intercalating species, and defects, can enhance the performance of Ni-based catalysts. It also delves into the active species involved in different reaction environments and the reaction mechanisms, including phase changes in the catalyst. The review identifies the limitations of current approaches and outlines future directions for improving OORs. The study discusses the mechanism of organic oxidation, focusing on the effects of reactant hydrophilicity, and the dynamic behavior of Ni valence states during OORs. It also examines the oxidation states of Ni in OORs, using techniques like XANES, XPS, and Raman spectroscopy, to determine their role in catalytic activity. The review highlights the importance of understanding the oxidation state of Ni in Ni-based catalysts for optimizing OORs and improving their efficiency and selectivity. The study also discusses the impact of phase changes on the selectivity and efficiency of product formation in OORs, emphasizing the need for a thorough understanding of the active catalyst phase during long-term OOR processes. The review concludes that Ni-based catalysts, with their dynamic redox behavior and ability to switch oxidation states, play a crucial role in facilitating OORs and enhancing their performance.