The article discusses the relationship between decision-making, the P3 component of event-related brain potentials (ERPs), and the locus coeruleus-norepinephrine (LC-NE) system. The P3 is a prominent ERP component that reflects the brain's response to stimuli, particularly in tasks involving decision-making. The authors argue that the P3 is closely linked to the LC-NE system, which is involved in modulating attention and arousal. The LC-NE system is thought to enhance the processing of information that is motivationally significant, and its phasic activity is associated with the P3. The P3 is influenced by factors such as the probability of a stimulus, its motivational significance, and the level of attention paid to it. The LC-NE system's role in decision-making is supported by evidence from both animal and human studies, including psychopharmacological experiments showing that manipulations of NE levels affect P3 amplitude. The review also highlights the importance of understanding the neural mechanisms underlying the P3, as this can provide insights into cognitive processes and disorders such as attention-deficit/hyperactivity disorder (ADHD). The LC-NE system is proposed as a key player in the generation of the P3, with its activity reflecting the outcome of internal decision-making processes and the subsequent effects of noradrenergic potentiation of information processing. The findings suggest that the P3 is a critical component in understanding how the brain processes information and makes decisions.The article discusses the relationship between decision-making, the P3 component of event-related brain potentials (ERPs), and the locus coeruleus-norepinephrine (LC-NE) system. The P3 is a prominent ERP component that reflects the brain's response to stimuli, particularly in tasks involving decision-making. The authors argue that the P3 is closely linked to the LC-NE system, which is involved in modulating attention and arousal. The LC-NE system is thought to enhance the processing of information that is motivationally significant, and its phasic activity is associated with the P3. The P3 is influenced by factors such as the probability of a stimulus, its motivational significance, and the level of attention paid to it. The LC-NE system's role in decision-making is supported by evidence from both animal and human studies, including psychopharmacological experiments showing that manipulations of NE levels affect P3 amplitude. The review also highlights the importance of understanding the neural mechanisms underlying the P3, as this can provide insights into cognitive processes and disorders such as attention-deficit/hyperactivity disorder (ADHD). The LC-NE system is proposed as a key player in the generation of the P3, with its activity reflecting the outcome of internal decision-making processes and the subsequent effects of noradrenergic potentiation of information processing. The findings suggest that the P3 is a critical component in understanding how the brain processes information and makes decisions.