A study published in JAMA Psychiatry analyzed 306,800 suicide decedents from 2003 to 2020 using latent class analysis to identify five distinct suicide profiles. These profiles include comorbid mental health and substance use disorders, mental health disorders alone, crisis, alcohol-related, and intimate partner problems, physical health problems, and polysubstance use. The largest profile, physical health problems (class 4), had the lowest rates of disclosing suicidal intent and leaving a suicide note, and was characterized by fewer mental health issues and psychotropic medications. Class 4 also had higher rates of older adults, veterans, and rural residents. The study highlights the need for tailored suicide prevention strategies that address the specific needs of each profile. It emphasizes the importance of integrated care for coexisting mental health conditions, substance and alcohol use disorders, and physical illnesses. The implementation of means restriction strategies is also crucial in reducing suicide risks across most profiles. The findings underscore the complexity of suicide and the need for a multifaceted approach to suicide prevention.A study published in JAMA Psychiatry analyzed 306,800 suicide decedents from 2003 to 2020 using latent class analysis to identify five distinct suicide profiles. These profiles include comorbid mental health and substance use disorders, mental health disorders alone, crisis, alcohol-related, and intimate partner problems, physical health problems, and polysubstance use. The largest profile, physical health problems (class 4), had the lowest rates of disclosing suicidal intent and leaving a suicide note, and was characterized by fewer mental health issues and psychotropic medications. Class 4 also had higher rates of older adults, veterans, and rural residents. The study highlights the need for tailored suicide prevention strategies that address the specific needs of each profile. It emphasizes the importance of integrated care for coexisting mental health conditions, substance and alcohol use disorders, and physical illnesses. The implementation of means restriction strategies is also crucial in reducing suicide risks across most profiles. The findings underscore the complexity of suicide and the need for a multifaceted approach to suicide prevention.